64Cu production, ligands and biomedical applications

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dc.contributor Helsingin yliopisto, Matemaattis-luonnontieteellinen tiedekunta, Kemian laitos fi
dc.contributor University of Helsinki, Faculty of Science, Department of Chemistry en
dc.contributor Helsingfors universitet, Matematisk-naturvetenskapliga fakulteten, Kemiska institutionen sv
dc.contributor.author Makkonen-Craig, Stewart
dc.date.issued 2006
dc.identifier.uri URN:NBN:fi-fe20061768
dc.identifier.uri http://hdl.handle.net/10138/21158
dc.description.abstract 64Cu (Iβ+ = 17%, Iβ− = 39%, IEC = 43%) is an important emerging biomedical radionuclide that is suitable for labelling a wide range of radiopharmaceuticals for PET imaging, as well as systemic or local radioimmunotherapy of tumours. Its positron energy spectrum is comparable with that of 18F, allowing high spatial resolution in PET imaging. Its intermediate half-life (12.7 h) permits PET evaluation of slow biochemical pathways, such as protein and peptide interactions with cellular targets, and distribution to satellite imaging and therapy centres. The optimum production route for radiochemically-pure, carrier-free 64Cu is via the reaction 64Ni(p,n) at 12 → 9 MeV followed by anion exchange chromatography. Biomedical applications follow three principal strategies: (i) direct application of 64Cu as a biological tracer, (ii) complexing with redox sensitive ligands (e.g. bisthiosemicarbazones) that release 64Cu upon reduction in hypoxic cells, and (iii) coordination with bifunctional ligands (e.g. tetraaza macrocycles) that covalently bond to intact antibodies, antibody fragments, peptides, peptide analogues or shell cross-linked nanoparticles for targeting receptors expressed by tumours. en
dc.language.iso en
dc.publisher Helsingfors universitet sv
dc.publisher University of Helsinki en
dc.publisher Helsingin yliopisto fi
dc.rights This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
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dc.title 64Cu production, ligands and biomedical applications en
dc.type.ontasot pro gradu-avhandlingar sv
dc.type.ontasot pro gradu -tutkielmat fi
dc.type.ontasot master's thesis en
dc.subject.discipline Radiochemistry en
dc.subject.discipline Radiokemia fi
dc.subject.discipline Radiokemi sv
dct.identifier.urn URN:NBN:fi-fe20061768

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