Skin Microbiome in Small- and Large-plaque Parapsoriasis

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http://hdl.handle.net/10138/211842

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Salava , A , Pereira , P , Aho , V , Vakeva , L , Paulin , L , Auvinen , P , Ranki , A & Lauerma , A 2017 , ' Skin Microbiome in Small- and Large-plaque Parapsoriasis ' , Acta Dermato-Venereologica , vol. 97 , no. 6 , 28175925 , pp. 685-691 . https://doi.org/10.2340/00015555-2631 , https://doi.org/10.2340/00015555-2631

Title: Skin Microbiome in Small- and Large-plaque Parapsoriasis
Author: Salava, Alexander; Pereira, Pedro; Aho, Velma; Vakeva, Liisa; Paulin, Lars; Auvinen, Petri; Ranki, Annamari; Lauerma, Antti
Contributor: University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, Institute of Biotechnology
University of Helsinki, University of Helsinki
University of Helsinki, Clinicum
University of Helsinki, University of Helsinki
University of Helsinki, University of Helsinki
University of Helsinki, University of Helsinki
University of Helsinki, Clinicum
Date: 2017-06
Language: eng
Number of pages: 7
Belongs to series: Acta Dermato-Venereologica
ISSN: 0001-5555
URI: http://hdl.handle.net/10138/211842
Abstract: Staphylococcal enterotoxins have been shown to promote lymphoma-associated immune dysregulation. This study examined changes in the skin microbiome of parapsoriasis compared with intact skin. Swab microbiome specimens were taken of the parapsoriasis lesions of 13 patients. Control samples were taken from contralateral healthy sides of the body. Micro-biotas were characterized by sequencing the V1-V3 region of the 16S ribosomal RNA bacterial genes on the Illumina MiSeq platform. The most common genera in the microbiome data were Propionibacterium (27.13%), Corynebacterium (21.20%) and Staphylococcus (4.63%). Out of the Staphylococcus sequences, 39.6% represented S. epidermidis, with the rest including S. hominis, S. capitis and unidentified species. No significant differences were observed between the patients' parapsoriasis and contralateral healthy skin or between large-and small-plaque parapsoriasis. Notable interpersonal variation was demonstrated. These results suggest that parapsoriasis is not associated with significant alterations in the cutaneous bacterial microbiome.
Subject: skin microbiome
cutaneous microbial diversity
cutaneous microbes
large-plaque parapsoriasis
small-plaque parapsoriasis
cutaneous T-cell lymphoma
T-CELL LYMPHOMA
ATOPIC-DERMATITIS
EN-PLAQUES
DIVERSITY
RNA
PROGRESSION
EVOLUTION
CHILDREN
3121 General medicine, internal medicine and other clinical medicine
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