An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers

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Blein , S , Bardel , C , Danjean , V , McGuffog , L , Healey , S , Barrowdale , D , Lee , A , Dennis , J , Kuchenbaecker , K B , Soucy , P , Terry , M B , Chung , W K , Goldgar , D E , Buys , S S , Janavicius , R , Tihomirova , L , Tung , N , Dorfling , C M , van Rensburg , E J , Neuhausen , S L , Ding , Y C , Gerdes , A-M , Ejlertsen , B , Nielsen , F C , Hansen , T V O , Osorio , A , Benitez , J , Andres Conejero , R , Segota , E , Weitzel , J N , Thelander , M , Peterlongo , P , Radice , P , Pensotti , V , Dolcetti , R , Bonanni , B , Peissel , B , Zaffaroni , D , Scuvera , G , Manoukian , S , Varesco , L , Capone , G L , Papi , L , Ottini , L , Yannoukakos , D , Konstantopoulou , I , Garber , J , Hamann , U , Donaldson , A , Brady , A , Brewer , C , Foo , C , Evans , D G , Frost , D , Eccles , D , Douglas , F , Cook , J , Adlard , J , Barwell , J , Walker , L , Izatt , L , Side , L E , Kennedy , M J , Tischkowitz , M , Rogers , M T , Porteous , M E , Morrison , P J , Platte , R , Eeles , R , Davidson , R , Hodgson , S , Cole , T , Godwin , A K , Isaacs , C , Claes , K , De Leeneer , K , Meindl , A , Gehrig , A , Wappenschmidt , B , Sutter , C , Engel , C , Niederacher , D , Steinemann , D , Plendl , H , Kast , K , Rhiem , K , Ditsch , N , Arnold , N , Varon-Mateeva , R , Schmutzler , R K , Preisler-Adams , S , Markov , N B , Wang-Gohrke , S , de Pauw , A , Lefol , C , Lasset , C , Leroux , D , Rouleau , E , Damiola , F , Dreyfus , H , Barjhoux , L , Golmard , L , Uhrhammer , N , Bonadona , V , Sornin , V , Bignon , Y-J , Carter , J , Van Le , L , Piedmonte , M , DiSilvestro , P A , de la Hoya , M , Caldes , T , Nevanlinna , H , Aittomaki , K , Jager , A , van den Ouweland , A M W , Kets , C M , Aalfs , C M , van Leeuwen , F E , Hogervorst , F B L , Meijers-Heijboer , H E J , Oosterwijk , J C , van Roozendaal , K E P , Rookus , M A , Devilee , P , van der Luijt , R B , Olah , E , Diez , O , Teule , A , Lazaro , C , Blanco , I , Del Valle , J , Jakubowska , A , Sukiennicki , G , Gronwald , J , Lubinski , J , Durda , K , Jaworska-Bieniek , K , Agnarsson , B A , Maugard , C , Amadori , A , Montagna , M , Teixeira , M R , Spurdle , A B , Foulkes , W , Olswold , C , Lindor , N M , Pankratz , V S , Szabo , C I , Lincoln , A , Jacobs , L , Corines , M , Robson , M , Vijai , J , Berger , A , Fink-Retter , A , Singer , C F , Rappaport , C , Kaulich , D G , Pfeiler , G , Tea , M-K , Greene , M H , Mai , P L , Rennert , G , Imyanitov , E N , Mulligan , A M , Glendon , G , Andrulis , I L , Tchatchou , S , Toland , A E , Pedersen , I S , Thomassen , M , Kruse , T A , Jensen , U B , Caligo , M A , Friedman , E , Zidan , J , Laitman , Y , Lindblom , A , Melin , B , Arver , B , Loman , N , Rosenquist , R , Olopade , O I , Nussbaum , R L , Ramus , S J , Nathanson , K L , Domchek , S M , Rebbeck , T R , Arun , B K , Mitchell , G , Karlan , B Y , Lester , J , Orsulic , S , Stoppa-Lyonnet , D , Thomas , G , Simard , J , Couch , F J , Offit , K , Easton , D F , Chenevix-Trench , G , Antoniou , A C , Mazoyer , S , Phelan , C M , Sinilnikova , O M , Cox , D G , Breast Canc Family Registry , EMBRACE , GEMO Study Collaborators & HEBON 2015 , ' An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers ' , Breast Cancer Research , vol. 17 , 61 . https://doi.org/10.1186/s13058-015-0567-2

Title: An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers
Author: Blein, Sophie; Bardel, Claire; Danjean, Vincent; McGuffog, Lesley; Healey, Sue; Barrowdale, Daniel; Lee, Andrew; Dennis, Joe; Kuchenbaecker, Karoline B.; Soucy, Penny; Terry, Mary Beth; Chung, Wendy K.; Goldgar, David E.; Buys, Saundra S.; Janavicius, Ramunas; Tihomirova, Laima; Tung, Nadine; Dorfling, Cecilia M.; van Rensburg, Elizabeth J.; Neuhausen, Susan L.; Ding, Yuan Chun; Gerdes, Anne-Marie; Ejlertsen, Bent; Nielsen, Finn C.; Hansen, Thomas V. O.; Osorio, Ana; Benitez, Javier; Andres Conejero, Raquel; Segota, Ena; Weitzel, Jeffrey N.; Thelander, Margo; Peterlongo, Paolo; Radice, Paolo; Pensotti, Valeria; Dolcetti, Riccardo; Bonanni, Bernardo; Peissel, Bernard; Zaffaroni, Daniela; Scuvera, Giulietta; Manoukian, Siranoush; Varesco, Liliana; Capone, Gabriele L.; Papi, Laura; Ottini, Laura; Yannoukakos, Drakoulis; Konstantopoulou, Irene; Garber, Judy; Hamann, Ute; Donaldson, Alan; Brady, Angela; Brewer, Carole; Foo, Claire; Evans, D. Gareth; Frost, Debra; Eccles, Diana; Douglas, Fiona; Cook, Jackie; Adlard, Julian; Barwell, Julian; Walker, Lisa; Izatt, Louise; Side, Lucy E.; Kennedy, M. John; Tischkowitz, Marc; Rogers, Mark T.; Porteous, Mary E.; Morrison, Patrick J.; Platte, Radka; Eeles, Ros; Davidson, Rosemarie; Hodgson, Shirley; Cole, Trevor; Godwin, Andrew K.; Isaacs, Claudine; Claes, Kathleen; De Leeneer, Kim; Meindl, Alfons; Gehrig, Andrea; Wappenschmidt, Barbara; Sutter, Christian; Engel, Christoph; Niederacher, Dieter; Steinemann, Doris; Plendl, Hansjoerg; Kast, Karin; Rhiem, Kerstin; Ditsch, Nina; Arnold, Norbert; Varon-Mateeva, Raymonda; Schmutzler, Rita K.; Preisler-Adams, Sabine; Markov, Nadja Bogdanova; Wang-Gohrke, Shan; de Pauw, Antoine; Lefol, Cedrick; Lasset, Christine; Leroux, Dominique; Rouleau, Etienne; Damiola, Francesca; Dreyfus, Helene; Barjhoux, Laure; Golmard, Lisa; Uhrhammer, Nancy; Bonadona, Valerie; Sornin, Valerie; Bignon, Yves-Jean; Carter, Jonathan; Van Le, Linda; Piedmonte, Marion; DiSilvestro, Paul A.; de la Hoya, Miguel; Caldes, Trinidad; Nevanlinna, Heli; Aittomaki, Kristiina; Jager, Agnes; van den Ouweland, Ans M. W.; Kets, Carolien M.; Aalfs, Cora M.; van Leeuwen, Flora E.; Hogervorst, Frans B. L.; Meijers-Heijboer, Hanne E. J.; Oosterwijk, Jan C.; van Roozendaal, Kees E. P.; Rookus, Matti A.; Devilee, Peter; van der Luijt, Rob B.; Olah, Edith; Diez, Orland; Teule, Alex; Lazaro, Conxi; Blanco, Ignacio; Del Valle, Jesus; Jakubowska, Anna; Sukiennicki, Grzegorz; Gronwald, Jacek; Lubinski, Jan; Durda, Katarzyna; Jaworska-Bieniek, Katarzyna; Agnarsson, Bjarni A.; Maugard, Christine; Amadori, Alberto; Montagna, Marco; Teixeira, Manuel R.; Spurdle, Amanda B.; Foulkes, William; Olswold, Curtis; Lindor, Noralane M.; Pankratz, Vernon S.; Szabo, Csilla I.; Lincoln, Anne; Jacobs, Lauren; Corines, Marina; Robson, Mark; Vijai, Joseph; Berger, Andreas; Fink-Retter, Anneliese; Singer, Christian F.; Rappaport, Christine; Kaulich, Daphne Geschwantler; Pfeiler, Georg; Tea, Muy-Kheng; Greene, Mark H.; Mai, Phuong L.; Rennert, Gad; Imyanitov, Evgeny N.; Mulligan, Anna Marie; Glendon, Gord; Andrulis, Irene L.; Tchatchou, Sandrine; Toland, Amanda Ewart; Pedersen, Inge Sokilde; Thomassen, Mads; Kruse, Torben A.; Jensen, Uffe Birk; Caligo, Maria A.; Friedman, Eitan; Zidan, Jamal; Laitman, Yael; Lindblom, Annika; Melin, Beatrice; Arver, Brita; Loman, Niklas; Rosenquist, Richard; Olopade, Olufunmilayo I.; Nussbaum, Robert L.; Ramus, Susan J.; Nathanson, Katherine L.; Domchek, Susan M.; Rebbeck, Timothy R.; Arun, Banu K.; Mitchell, Gillian; Karlan, Beth Y.; Lester, Jenny; Orsulic, Sandra; Stoppa-Lyonnet, Dominique; Thomas, Gilles; Simard, Jacques; Couch, Fergus J.; Offit, Kenneth; Easton, Douglas F.; Chenevix-Trench, Georgia; Antoniou, Antonis C.; Mazoyer, Sylvie; Phelan, Catherine M.; Sinilnikova, Olga M.; Cox, David G.; Breast Canc Family Registry; EMBRACE; GEMO Study Collaborators; HEBON
Contributor: University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Medicum
Date: 2015-04-25
Language: eng
Number of pages: 15
Belongs to series: Breast Cancer Research
ISSN: 1465-5411
URI: http://hdl.handle.net/10138/212209
Abstract: Introduction: Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals with different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. In the present study, we tested the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1/2 mutation carriers. Methods: We genotyped 22,214 (11,421 affected, 10,793 unaffected) mutation carriers belonging to the Consortium of Investigators of Modifiers of BRCA1/2 for 129 mitochondrial polymorphisms using the iCOGS array. Haplogroup inference and association detection were performed using a phylogenetic approach. ALTree was applied to explore the reference mitochondrial evolutionary tree and detect subclades enriched in affected or unaffected individuals. Results: We discovered that subclade T1a1 was depleted in affected BRCA2 mutation carriers compared with the rest of clade T (hazard ratio (HR) = 0.55; 95% confidence interval (CI), 0.34 to 0.88; P = 0.01). Compared with the most frequent haplogroup in the general population (that is, H and T clades), the T1a1 haplogroup has a HR of 0.62 (95% CI, 0.40 to 0.95; P = 0.03). We also identified three potential susceptibility loci, including G13708A/rs28359178, which has demonstrated an inverse association with familial breast cancer risk. Conclusions: This study illustrates how original approaches such as the phylogeny-based method we used can empower classical molecular epidemiological studies aimed at identifying association or risk modification effects.
Subject: SINGLE-NUCLEOTIDE POLYMORPHISMS
GENETIC MODIFIERS
OXIDATIVE STRESS
DNA HAPLOGROUPS
SUSCEPTIBILITY
OVARIAN
CONSORTIUM
VARIANTS
MULTIPLE
DISEASES
3122 Cancers
3123 Gynaecology and paediatrics
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