Meta-analysis of Genome-Wide Association Studies for Extraversion : Findings from the Genetics of Personality Consortium

Show full item record



Permalink

http://hdl.handle.net/10138/212583

Citation

van den Berg , S M , de Moor , M H M , Verweij , K J H , Krueger , R F , Luciano , M , Vasquez , A A , Matteson , L K , Derringer , J , Esko , T , Amin , N , Gordon , S D , Hansell , N K , Hart , A B , Seppala , I , Huffman , J E , Konte , B , Lahti , J , Lee , M , Miller , M , Nutile , T , Tanaka , T , Teumer , A , Viktorin , A , Wedenoja , J , Abdellaoui , A , Abecasis , G R , Adkins , D E , Agrawal , A , Allik , J , Appel , K , Bigdeli , T B , Busonero , F , Campbell , H , Costa , P T , Smith , G D , Davies , G , de Wit , H , Ding , J , Engelhardt , B E , Eriksson , J G , Heinonen , K , Jokela , M , Latvala , A , Palotie , A , Pulkki-Raback , L , Vuoksimaa , E , Widen , E , Kaprio , J , Räikkönen , K , Keltikangas-Jarvinen , L & Generation Scotland 2016 , ' Meta-analysis of Genome-Wide Association Studies for Extraversion : Findings from the Genetics of Personality Consortium ' , Behavior Genetics , vol. 46 , no. 2 , pp. 170-182 . https://doi.org/10.1007/s10519-015-9735-5

Title: Meta-analysis of Genome-Wide Association Studies for Extraversion : Findings from the Genetics of Personality Consortium
Author: van den Berg, Stephanie M.; de Moor, Marleen H. M.; Verweij, Karin J. H.; Krueger, Robert F.; Luciano, Michelle; Vasquez, Alejandro Arias; Matteson, Lindsay K.; Derringer, Jaime; Esko, Tonu; Amin, Najaf; Gordon, Scott D.; Hansell, Narelle K.; Hart, Amy B.; Seppala, Ilkka; Huffman, Jennifer E.; Konte, Bettina; Lahti, Jari; Lee, Minyoung; Miller, Mike; Nutile, Teresa; Tanaka, Toshiko; Teumer, Alexander; Viktorin, Alexander; Wedenoja, Juho; Abdellaoui, Abdel; Abecasis, Goncalo R.; Adkins, Daniel E.; Agrawal, Arpana; Allik, Jueri; Appel, Katja; Bigdeli, Timothy B.; Busonero, Fabio; Campbell, Harry; Costa, Paul T.; Smith, George Davey; Davies, Gail; de Wit, Harriet; Ding, Jun; Engelhardt, Barbara E.; Eriksson, Johan G.; Heinonen, Kati; Jokela, Markus; Latvala, Antti; Palotie, Aarno; Pulkki-Raback, Laura; Vuoksimaa, Eero; Widen, Elisabeth; Kaprio, Jaakko; Räikkönen, Katri; Keltikangas-Jarvinen, Liisa; Generation Scotland
Contributor: University of Helsinki, Helsinki Collegium for Advanced Studies
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Behavioural Sciences
University of Helsinki, Behavioural Sciences
University of Helsinki, Clinicum
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Helsinki Collegium for Advanced Studies
University of Helsinki, Clinicum
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
University of Helsinki, Behavioural Sciences
University of Helsinki, Behavioural Sciences
Date: 2016-03
Language: eng
Number of pages: 13
Belongs to series: Behavior Genetics
ISSN: 0001-8244
URI: http://hdl.handle.net/10138/212583
Abstract: Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.
Subject: Personality
Phenotype harmonization
Common genetic variants
Imputation
Polygenic risk
COMMON SNPS EXPLAIN
CLONINGERS TEMPERAMENT SCALES
NEUROTROPHIC FACTOR BDNF
PSYCHOBIOLOGICAL MODEL
LARGE PROPORTION
5-FACTOR MODEL
HUMAN HEIGHT
HERITABILITY
NEUROTICISM
DIMENSIONS
515 Psychology
3142 Public health care science, environmental and occupational health
3111 Biomedicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
10.1007_s10519_015_9735_5.pdf 683.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record