Meta-analysis of Genome-Wide Association Studies for Extraversion : Findings from the Genetics of Personality Consortium

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van den Berg , S M , de Moor , M H M , Verweij , K J H , Krueger , R F , Luciano , M , Vasquez , A A , Matteson , L K , Derringer , J , Esko , T , Amin , N , Gordon , S D , Hansell , N K , Hart , A B , Seppala , I , Huffman , J E , Konte , B , Lahti , J , Lee , M , Miller , M , Nutile , T , Tanaka , T , Teumer , A , Viktorin , A , Wedenoja , J , Abdellaoui , A , Abecasis , G R , Adkins , D E , Agrawal , A , Allik , J , Appel , K , Bigdeli , T B , Busonero , F , Campbell , H , Costa , P T , Smith , G D , Davies , G , de Wit , H , Ding , J , Engelhardt , B E , Eriksson , J G , Heinonen , K , Jokela , M , Latvala , A , Palotie , A , Pulkki-Raback , L , Vuoksimaa , E , Widen , E , Kaprio , J , Räikkönen , K , Keltikangas-Jarvinen , L & Generation Scotland 2016 , ' Meta-analysis of Genome-Wide Association Studies for Extraversion : Findings from the Genetics of Personality Consortium ' , Behavior Genetics , vol. 46 , no. 2 , pp. 170-182 .

Title: Meta-analysis of Genome-Wide Association Studies for Extraversion : Findings from the Genetics of Personality Consortium
Author: van den Berg, Stephanie M.; de Moor, Marleen H. M.; Verweij, Karin J. H.; Krueger, Robert F.; Luciano, Michelle; Vasquez, Alejandro Arias; Matteson, Lindsay K.; Derringer, Jaime; Esko, Tonu; Amin, Najaf; Gordon, Scott D.; Hansell, Narelle K.; Hart, Amy B.; Seppala, Ilkka; Huffman, Jennifer E.; Konte, Bettina; Lahti, Jari; Lee, Minyoung; Miller, Mike; Nutile, Teresa; Tanaka, Toshiko; Teumer, Alexander; Viktorin, Alexander; Wedenoja, Juho; Abdellaoui, Abdel; Abecasis, Goncalo R.; Adkins, Daniel E.; Agrawal, Arpana; Allik, Jueri; Appel, Katja; Bigdeli, Timothy B.; Busonero, Fabio; Campbell, Harry; Costa, Paul T.; Smith, George Davey; Davies, Gail; de Wit, Harriet; Ding, Jun; Engelhardt, Barbara E.; Eriksson, Johan G.; Heinonen, Kati; Jokela, Markus; Latvala, Antti; Palotie, Aarno; Pulkki-Raback, Laura; Vuoksimaa, Eero; Widen, Elisabeth; Kaprio, Jaakko; Räikkönen, Katri; Keltikangas-Jarvinen, Liisa; Generation Scotland
Contributor organization: Helsinki Collegium for Advanced Studies
Behavioural Sciences
Department of Public Health
Johan Eriksson / Principal Investigator
Department of General Practice and Primary Health Care
Diabetes and Obesity Research Program
Research Programs Unit
Institute for Molecular Medicine Finland
Aarno Palotie / Principal Investigator
Elisabeth Ingrid Maria Widen / Principal Investigator
Jaakko Kaprio / Principal Investigator
Psychosocial factors and health
Developmental Psychology Research Group
Genomics of Neurological and Neuropsychiatric Disorders
Genetic Epidemiology
Genomic Discoveries and Clinical Translation
Date: 2016-03
Language: eng
Number of pages: 13
Belongs to series: Behavior Genetics
ISSN: 0001-8244
Abstract: Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.
Subject: Personality
Phenotype harmonization
Common genetic variants
Polygenic risk
515 Psychology
3142 Public health care science, environmental and occupational health
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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