Cancer incidence in persons with type 1 diabetes : a five-country study of 9,000 cancers in type 1 diabetic individuals

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Carstensen , B , Read , S H , Friis , S , Sund , R , Keskimaki , I , Svensson , A-M , Ljung , R , Wild , S H , Kerssens , J J , Harding , J L , Magliano , D J , Gudbjornsdottir , S & Diabet Canc Res Consortium 2016 , ' Cancer incidence in persons with type 1 diabetes : a five-country study of 9,000 cancers in type 1 diabetic individuals ' Diabetologia , vol. 59 , no. 5 , pp. 980-988 . DOI: 10.1007/s00125-016-3884-9

Title: Cancer incidence in persons with type 1 diabetes : a five-country study of 9,000 cancers in type 1 diabetic individuals
Author: Carstensen, Bendix; Read, Stephanie H.; Friis, Soren; Sund, Reijo; Keskimaki, Ilmo; Svensson, Ann-Marie; Ljung, Rickard; Wild, Sarah H.; Kerssens, Joannes J.; Harding, Jessica L.; Magliano, Dianna J.; Gudbjornsdottir, Soffia; Diabet Canc Res Consortium
Contributor: University of Helsinki, Department of Social Research
Date: 2016-05
Language: eng
Number of pages: 9
Belongs to series: Diabetologia
ISSN: 0012-186X
URI: http://hdl.handle.net/10138/212594
Abstract: An excess cancer incidence of 20-25% has been identified among persons with diabetes, most of whom have type 2 diabetes. We aimed to describe the association between type 1 diabetes and cancer incidence. Persons with type 1 diabetes were identified from five nationwide diabetes registers: Australia (2000-2008), Denmark (1995-2014), Finland (1972-2012), Scotland (1995-2012) and Sweden (1987-2012). Linkage to national cancer registries provided the numbers of incident cancers in people with type 1 diabetes and in the general population. We used Poisson models with adjustment for age and date of follow up to estimate hazard ratios for total and site-specific cancers. A total of 9,149 cancers occurred among persons with type 1 diabetes in 3.9 million person-years. The median age at cancer diagnosis was 51.1 years (interquartile range 43.5-59.5). The hazard ratios (HRs) (95% CIs) associated with type 1 diabetes for all cancers combined were 1.01 (0.98, 1.04) among men and 1.07 (1.04, 1.10) among women. HRs were increased for cancer of the stomach (men, HR 1.23 [1.04, 1.46]; women, HR 1.78 [1.49, 2.13]), liver (men, HR 2.00 [1.67, 2.40]; women, HR 1.55 [1.14, 2.10]), pancreas (men, HR 1.53 [1.30, 1.79]; women, HR 1.25 [1.02,1.53]), endometrium (HR 1.42 [1.27, 1.58]) and kidney (men, HR 1.30 [1.12, 1.49]; women, HR 1.47 [1.23, 1.77]). Reduced HRs were found for cancer of the prostate (HR 0.56 [0.51, 0.61]) and breast (HR 0.90 [0.85, 0.94]). HRs declined with increasing diabetes duration. Type 1 diabetes was associated with differences in the risk of several common cancers; the strength of these associations varied with the duration of diabetes.
Subject: Cancer incidence
Cancer rate ratio
Cancer subtypes
Diabetes duration
POPULATION-BASED COHORT
SEX-HORMONE LEVELS
PROSTATE-CANCER
PANCREATIC-CANCER
MELLITUS
RISK
METAANALYSIS
ASSOCIATIONS
SWEDEN
MORTALITY
3122 Cancers
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