The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children-Analyses based on path models

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dc.contributor.author Wolters, Maike
dc.contributor.author Dering, Carmen
dc.contributor.author Siani, Alfonso
dc.contributor.author Russo, Paola
dc.contributor.author Kaprio, Jaakko
dc.contributor.author Rise, Patrizia
dc.contributor.author Moreno, Luis A.
dc.contributor.author De Henauw, Stefaan
dc.contributor.author Mehlig, Kirsten
dc.contributor.author Veidebaum, Toomas
dc.contributor.author Molnar, Denes
dc.contributor.author Tornaritis, Michael
dc.contributor.author Iacoviello, Licia
dc.contributor.author Pitsiladis, Yannis
dc.contributor.author Galli, Claudio
dc.contributor.author Foraita, Ronja
dc.contributor.author Bornhorst, Claudia
dc.contributor.author IDEFICS
dc.contributor.author I Family Consortia
dc.date.accessioned 2017-08-25T05:46:02Z
dc.date.available 2017-08-25T05:46:02Z
dc.date.issued 2017-07-21
dc.identifier.citation Wolters , M , Dering , C , Siani , A , Russo , P , Kaprio , J , Rise , P , Moreno , L A , De Henauw , S , Mehlig , K , Veidebaum , T , Molnar , D , Tornaritis , M , Iacoviello , L , Pitsiladis , Y , Galli , C , Foraita , R , Bornhorst , C , IDEFICS & I Family Consortia 2017 , ' The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children-Analyses based on path models ' , PLoS One , vol. 12 , no. 7 , 0181485 . https://doi.org/10.1371/journal.pone.0181485
dc.identifier.other PURE: 88769526
dc.identifier.other PURE UUID: 29afe559-3c51-409b-955c-5e7136dccb66
dc.identifier.other WOS: 000406643100040
dc.identifier.other Scopus: 85025171009
dc.identifier.uri http://hdl.handle.net/10138/215601
dc.description.abstract Background The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP. Methods A subsample of the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) baseline survey including 520 children aged 2 to Results Minor allele carriers of the SNP rs174546 had significantly higher DGLA and lower ARA and EPA levels as well as a lower D5D index. Via ARA and BMI z-score, the polymorphism had an indirect lowering effect on systolic BP z-score for each additional T allele (standardized effect estimate -0.057, p = 0.007). For DGLA, EPA and D5D index, the indirect effects of rs174546 on systolic BP were also negative but did not reach significance. DGLA and EPA had an increasing indirect effect on systolic BP via BMI. Results for diastolic BP were in general similar but effect estimates were lower compared to systolic BP. Conclusion Genetic variation in FADS1 influences BP via ARA and BMI indicating a favorable effect of the minor allele in SNP rs174546. Thus, polymorphisms with an impact on the D5D activity may play a role for the BP level mediated through PUFA and BMI. Therefore, health effects of dietary n-6 and n-3 PUFA may vary depending on genetic FADS1 variants. en
dc.format.extent 17
dc.language.iso eng
dc.relation.ispartof PLoS One
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject GENOME-WIDE ASSOCIATION
dc.subject CARDIOVASCULAR RISK-FACTORS
dc.subject GENE-CLUSTER
dc.subject WHOLE-BLOOD
dc.subject DESATURASE ACTIVITIES
dc.subject REFERENCE VALUES
dc.subject QUALITY-CONTROL
dc.subject ADIPOSE-TISSUE
dc.subject PLASMA
dc.subject ADOLESCENTS
dc.subject 3111 Biomedicine
dc.title The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children-Analyses based on path models en
dc.type Article
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization University of Helsinki
dc.contributor.organization Genetic Epidemiology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1371/journal.pone.0181485
dc.relation.issn 1932-6203
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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