Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity

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Ahola , A J , Lassenius , M I , Forsblom , C , Harjutsalo , V , Lehto , M & Groop , P-H 2017 , ' Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity ' , Scientific Reports , vol. 7 , 6511 . https://doi.org/10.1038/s41598-017-06885-7

Title: Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity
Author: Ahola, Aila J.; Lassenius, Mariann I.; Forsblom, Carol; Harjutsalo, Valma; Lehto, Markku; Groop, Per-Henrik
Contributor: University of Helsinki, University of Helsinki
University of Helsinki, Nefrologian yksikkö
University of Helsinki, Clinicum
University of Helsinki, University of Helsinki
University of Helsinki, Nefrologian yksikkö
University of Helsinki, Clinicum
Date: 2017-07-26
Language: eng
Number of pages: 9
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/215608
Abstract: Gram-negative bacteria-derived lipopolysaccharides (LPS) are associated with various negative health effects. Whether diet is associated with LPS, is an understudied phenomenon. We investigated the association between diet and serum LPS activity in 668 individuals with type 1 diabetes in the FinnDiane Study. Serum LPS activity was determined using the Limulus Amoebocyte Lysate assay. Diet was assessed with a food frequency questionnaire (FFQ) section of a diet questionnaire and a food record. The food record was used to calculate energy, macronutrient, and fibre intake. In a multivariable model, energy, macronutrient, or fibre intake was not associated with the LPS activity. Using factor analysis, we identified seven dietary patterns from the FFQ data ("Sweet", "Cheese", "Fish", "Healthy snack", "Vegetable", "Traditional", and "Modern"). In a multivariable model, higher factor scores of the Fish, Healthy snack, and Modern patterns predicted lower LPS activity. The validity of the diet questionnaire was also investigated. The questionnaire showed reasonable relative validity against a 6-day food record. The two methods classified participants into the dietary patterns better than expected by chance. In conclusion, healthy dietary choices, such as consumption of fish, fresh vegetables, and fruits and berries may be associated with positive health outcomes by reducing systemic endotoxaemia.
Subject: INTESTINAL PERMEABILITY
METABOLIC ENDOTOXEMIA
GLYCEMIC CONTROL
GUT MICROBIOTA
WEANED PIGS
INFLAMMATION
OBESITY
WOMEN
DISEASE
PATHOGENESIS
3121 General medicine, internal medicine and other clinical medicine
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