Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

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Antila , H , Ryazantseva , M , Popova , D , Sipilä , P , Guirado , R , Kohtala , S , Yalcin , I , Lindholm , J , Vesa , L , Sato , V , Cordeira , J , Autio , H , Kislin , M , Rios , M , Joca , S , Casarotto , P , Khiroug , L , Lauri , S , Taira , T , Castren , E & Rantamäki , T 2017 , ' Isoflurane produces antidepressant effects and induces TrkB signaling in rodents ' , Scientific Reports , vol. 7 , 7811 . https://doi.org/10.1038/s41598-017-08166-9

Title: Isoflurane produces antidepressant effects and induces TrkB signaling in rodents
Author: Antila, Hanna; Ryazantseva, Maria; Popova, Dina; Sipilä, Pia; Guirado, Ramon; Kohtala, Samuel; Yalcin, Ipek; Lindholm, Jesse; Vesa, Liisa; Sato, Vinicius; Cordeira, Joshua; Autio, Henri; Kislin, Mikhail; Rios, Maribel; Joca, Samia; Casarotto, Plinio; Khiroug, Leonard; Lauri, Sari; Taira, Tomi; Castren, Eero; Rantamäki, Tomi
Contributor organization: Neuroscience Center
Biosciences
Syn­aptic Plas­ti­city and De­vel­op­ment
Physiology and Neuroscience (-2020)
Departments of Faculty of Veterinary Medicine
Tomi Taira / Principal Investigator
Veterinary Biosciences
Veterinary Physiology
Eero Castren / Principal Investigator
Helsinki In Vivo Animal Imaging Platform (HAIP)
Laboratory of Neurotherapeutics
Date: 2017-08-10
Language: eng
Number of pages: 12
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-017-08166-9
URI: http://hdl.handle.net/10138/217887
Abstract: A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned helplessness paradigm and regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketamine: activation of brain-derived neurotrophic factor (BDNF) receptor TrkB, facilitation of mammalian target of rapamycin (mTOR) signaling pathway and inhibition of glycogen synthase kinase 3 beta (GSK3 beta). Moreover, isoflurane affected neuronal plasticity by facilitating long-term potentiation in the hippocampus. We also found that isoflurane increased activity of the parvalbumin interneurons, and facilitated GABAergic transmission in wild type mice but not in transgenic mice with reduced TrkB expression in parvalbumin interneurons. Our findings strengthen the role of TrkB signaling in the antidepressant responses and encourage further evaluation of isoflurane as a rapid-acting antidepressant devoid of the psychotomimetic effects and abuse potential of ketamine.
Subject: MEDIAL PREFRONTAL CORTEX
NEUROPATHIC PAIN
NEUROTROPHIN RECEPTOR
DEPRESSED-PATIENTS
DENDRITIC SPINES
ANESTHESIA
MICE
HIPPOCAMPUS
INHIBITION
KETAMINE
3112 Neurosciences
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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