An interaction map of circulating metabolites, immune gene networks, and their genetic regulation

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Nath , A P , Ritchie , S C , Byars , S G , Fearnley , L G , Havulinna , A S , Joensuu , A , Kangas , A J , Soininen , P , Wennerstrom , A , Milani , L , Metspalu , A , Mannisto , S , Wurtz , P , Kettunen , J , Raitoharju , E , Kahonen , M , Juonala , M , Palotie , A , Ala-Korpela , M , Ripatti , S , Lehtimaki , T , Abraham , G , Raitakari , O , Salomaa , V , Perola , M & Inouye , M 2017 , ' An interaction map of circulating metabolites, immune gene networks, and their genetic regulation ' , Genome Biology , vol. 18 , 146 . https://doi.org/10.1186/s13059-017-1279-y

Title: An interaction map of circulating metabolites, immune gene networks, and their genetic regulation
Author: Nath, Artika P.; Ritchie, Scott C.; Byars, Sean G.; Fearnley, Liam G.; Havulinna, Aki S.; Joensuu, Anni; Kangas, Antti J.; Soininen, Pasi; Wennerstrom, Annika; Milani, Lili; Metspalu, Andres; Mannisto, Satu; Wurtz, Peter; Kettunen, Johannes; Raitoharju, Emma; Kahonen, Mika; Juonala, Markus; Palotie, Aarno; Ala-Korpela, Mika; Ripatti, Samuli; Lehtimaki, Terho; Abraham, Gad; Raitakari, Olli; Salomaa, Veikko; Perola, Markus; Inouye, Michael
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, National Institute for Health and Welfare (THL)
University of Helsinki, Research Programs Unit
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2017-08-01
Language: eng
Number of pages: 15
Belongs to series: Genome Biology
ISSN: 1474-760X
URI: http://hdl.handle.net/10138/220542
Abstract: Background: Immunometabolism plays a central role in many cardiometabolic diseases. However, a robust map of immune-related gene networks in circulating human cells, their interactions with metabolites, and their genetic control is still lacking. Here, we integrate blood transcriptomic, metabolomic, and genomic profiles from two population-based cohorts (total N = 2168), including a subset of individuals with matched multi-omic data at 7-year follow-up. Results: We identify topologically replicable gene networks enriched for diverse immune functions including cytotoxicity, viral response, B cell, platelet, neutrophil, and mast cell/basophil activity. These immune gene modules show complex patterns of association with 158 circulating metabolites, including lipoprotein subclasses, lipids, fatty acids, amino acids, small molecules, and CRP. Genome-wide scans for module expression quantitative trait loci (mQTLs) reveal five modules with mQTLs that have both cis and trans effects. The strongest mQTL is in ARHGEF3 (rs1354034) and affects a module enriched for platelet function, independent of platelet counts. Modules of mast cell/basophil and neutrophil function show temporally stable metabolite associations over 7-year follow-up, providing evidence that these modules and their constituent gene products may play central roles in metabolic inflammation. Furthermore, the strongest mQTL in ARHGEF3 also displays clear temporal stability, supporting widespread trans effects at this locus. Conclusions: This study provides a detailed map of natural variation at the blood immunometabolic interface and its genetic basis, and may facilitate subsequent studies to explain inter-individual variation in cardiometabolic disease.
Subject: NATURAL-KILLER-CELLS
CARDIOVASCULAR RISK
INSULIN-RESISTANCE
YOUNG FINNS
ADIPOSE-TISSUE
HOST-DEFENSE
B-CELLS
PLATELET
IDENTIFICATION
RECEPTOR
3111 Biomedicine
1184 Genetics, developmental biology, physiology
318 Medical biotechnology
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