Blood Pressure in 6-Year-Old Children Born Extremely Preterm

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Bonamy , A-K E , Mohlkert , L-A , Hallberg , J , Liuba , P , Fellman , V , Domellof , M & Norman , M 2017 , ' Blood Pressure in 6-Year-Old Children Born Extremely Preterm ' , Journal of the American Heart Association , vol. 6 , no. 8 , 005858 .

Title: Blood Pressure in 6-Year-Old Children Born Extremely Preterm
Author: Bonamy, Anna-Karin Edstedt; Mohlkert, Lilly-Ann; Hallberg, Jenny; Liuba, Petru; Fellman, Vineta; Domellof, Magnus; Norman, Mikael
Contributor organization: Children's Hospital
Lastentautien yksikkö
University of Helsinki
HUS Children and Adolescents
Date: 2017-08
Language: eng
Number of pages: 8
Belongs to series: Journal of the American Heart Association
ISSN: 2047-9980
Abstract: Background-Advances in perinatal medicine have increased infant survival after very preterm birth. Although this progress is welcome, there is increasing concern that preterm birth is an emerging risk factor for hypertension at young age, with implications for the lifetime risk of cardiovascular disease. Methods and Results-We measured casual blood pressures (BPs) in a population-based cohort of 6-year-old survivors of extremely preterm birth (<27 gestational weeks; n=171) and in age-and sex-matched controls born at term (n=172). Measured BP did not differ, but sex, age-, and height-adjusted median z scores were 0.14 SD higher (P=0.02) for systolic BP and 0.10 SD higher (P=0.01) for diastolic BP in children born extremely preterm than in controls. Among children born extremely preterm, shorter gestation, higher body mass index, and higher heart rate at follow-up were all independently associated with higher BP at 6 years of age, whereas preeclampsia, smoking in pregnancy, neonatal morbidity, and perinatal corticosteroid therapy were not. In multivariate regression analyses, systolic BP decreased by 0.10 SD (P=0.08) and diastolic BP by 0.09 SD (P=0.02) for each week-longer gestation. Conclusions-Six-year-old children born extremely preterm have normal but slightly higher BP than their peers born at term. Although this finding is reassuring for children born preterm and their families, follow-up at older age is warranted.
Subject: follow-up study
preterm birth
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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