Blood Pressure in 6-Year-Old Children Born Extremely Preterm

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http://hdl.handle.net/10138/222913

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Bonamy , A-K E , Mohlkert , L-A , Hallberg , J , Liuba , P , Fellman , V , Domellof , M & Norman , M 2017 , ' Blood Pressure in 6-Year-Old Children Born Extremely Preterm ' , Journal of the American Heart Association , vol. 6 , no. 8 , 005858 . https://doi.org/10.1161/JAHA.117.005858

Titel: Blood Pressure in 6-Year-Old Children Born Extremely Preterm
Författare: Bonamy, Anna-Karin Edstedt; Mohlkert, Lilly-Ann; Hallberg, Jenny; Liuba, Petru; Fellman, Vineta; Domellof, Magnus; Norman, Mikael
Upphovmannens organisation: Children's Hospital
Lastentautien yksikkö
Clinicum
University of Helsinki
HUS Children and Adolescents
Datum: 2017-08
Språk: eng
Sidantal: 8
Tillhör serie: Journal of the American Heart Association
ISSN: 2047-9980
DOI: https://doi.org/10.1161/JAHA.117.005858
Permanenta länken (URI): http://hdl.handle.net/10138/222913
Abstrakt: Background-Advances in perinatal medicine have increased infant survival after very preterm birth. Although this progress is welcome, there is increasing concern that preterm birth is an emerging risk factor for hypertension at young age, with implications for the lifetime risk of cardiovascular disease. Methods and Results-We measured casual blood pressures (BPs) in a population-based cohort of 6-year-old survivors of extremely preterm birth (<27 gestational weeks; n=171) and in age-and sex-matched controls born at term (n=172). Measured BP did not differ, but sex, age-, and height-adjusted median z scores were 0.14 SD higher (P=0.02) for systolic BP and 0.10 SD higher (P=0.01) for diastolic BP in children born extremely preterm than in controls. Among children born extremely preterm, shorter gestation, higher body mass index, and higher heart rate at follow-up were all independently associated with higher BP at 6 years of age, whereas preeclampsia, smoking in pregnancy, neonatal morbidity, and perinatal corticosteroid therapy were not. In multivariate regression analyses, systolic BP decreased by 0.10 SD (P=0.08) and diastolic BP by 0.09 SD (P=0.02) for each week-longer gestation. Conclusions-Six-year-old children born extremely preterm have normal but slightly higher BP than their peers born at term. Although this finding is reassuring for children born preterm and their families, follow-up at older age is warranted.
Subject: follow-up study
hypertension
pediatrics
preterm birth
LOW-BIRTH-WEIGHT
YOUNG-ADULTS BORN
ISCHEMIC-HEART-DISEASE
CARDIOVASCULAR RISK
GESTATIONAL-AGE
FOLLOW-UP
INFANTS
HYPERTENSION
CHILDHOOD
MORTALITY
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
Referentgranskad: Ja
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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