Blood Pressure in 6-Year-Old Children Born Extremely Preterm

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dc.contributor.author Bonamy, Anna-Karin Edstedt
dc.contributor.author Mohlkert, Lilly-Ann
dc.contributor.author Hallberg, Jenny
dc.contributor.author Liuba, Petru
dc.contributor.author Fellman, Vineta
dc.contributor.author Domellof, Magnus
dc.contributor.author Norman, Mikael
dc.date.accessioned 2017-09-12T10:28:00Z
dc.date.available 2017-09-12T10:28:00Z
dc.date.issued 2017-08
dc.identifier.citation Bonamy , A-K E , Mohlkert , L-A , Hallberg , J , Liuba , P , Fellman , V , Domellof , M & Norman , M 2017 , ' Blood Pressure in 6-Year-Old Children Born Extremely Preterm ' , Journal of the American Heart Association , vol. 6 , no. 8 , 005858 . https://doi.org/10.1161/JAHA.117.005858
dc.identifier.other PURE: 89561366
dc.identifier.other PURE UUID: 845190b8-1aef-4350-a572-29861ab9e75e
dc.identifier.other WOS: 000406948200014
dc.identifier.other Scopus: 85030663120
dc.identifier.uri http://hdl.handle.net/10138/222913
dc.description.abstract Background-Advances in perinatal medicine have increased infant survival after very preterm birth. Although this progress is welcome, there is increasing concern that preterm birth is an emerging risk factor for hypertension at young age, with implications for the lifetime risk of cardiovascular disease. Methods and Results-We measured casual blood pressures (BPs) in a population-based cohort of 6-year-old survivors of extremely preterm birth (<27 gestational weeks; n=171) and in age-and sex-matched controls born at term (n=172). Measured BP did not differ, but sex, age-, and height-adjusted median z scores were 0.14 SD higher (P=0.02) for systolic BP and 0.10 SD higher (P=0.01) for diastolic BP in children born extremely preterm than in controls. Among children born extremely preterm, shorter gestation, higher body mass index, and higher heart rate at follow-up were all independently associated with higher BP at 6 years of age, whereas preeclampsia, smoking in pregnancy, neonatal morbidity, and perinatal corticosteroid therapy were not. In multivariate regression analyses, systolic BP decreased by 0.10 SD (P=0.08) and diastolic BP by 0.09 SD (P=0.02) for each week-longer gestation. Conclusions-Six-year-old children born extremely preterm have normal but slightly higher BP than their peers born at term. Although this finding is reassuring for children born preterm and their families, follow-up at older age is warranted. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Journal of the American Heart Association
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject follow-up study
dc.subject hypertension
dc.subject pediatrics
dc.subject preterm birth
dc.subject LOW-BIRTH-WEIGHT
dc.subject YOUNG-ADULTS BORN
dc.subject ISCHEMIC-HEART-DISEASE
dc.subject CARDIOVASCULAR RISK
dc.subject GESTATIONAL-AGE
dc.subject FOLLOW-UP
dc.subject INFANTS
dc.subject HYPERTENSION
dc.subject CHILDHOOD
dc.subject MORTALITY
dc.subject 3123 Gynaecology and paediatrics
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Blood Pressure in 6-Year-Old Children Born Extremely Preterm en
dc.type Article
dc.contributor.organization Children's Hospital
dc.contributor.organization Lastentautien yksikkö
dc.contributor.organization Clinicum
dc.contributor.organization University of Helsinki
dc.contributor.organization HUS Children and Adolescents
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1161/JAHA.117.005858
dc.relation.issn 2047-9980
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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