Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine

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Soderholm , S , Anastasina , M , Islam , M M , Tynell , J , Poranen , M M , Bamford , D H , Stenman , J , Julkunen , I , Sauliene , I , De Brabander , J K , Matikainen , S , Nyman , T A , Saelens , X & Kainov , D 2016 , ' Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine ' , Antiviral Research , vol. 126 , pp. 69-80 . https://doi.org/10.1016/j.antiviral.2015.12.011

Title: Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine
Author: Soderholm, Sandra; Anastasina, Maria; Islam, Mohammad Majharul; Tynell, Janne; Poranen, Minna M.; Bamford, Dennis H.; Stenman, Jakob; Julkunen, Ilkka; Sauliene, Ingrida; De Brabander, Jef K.; Matikainen, Sampsa; Nyman, Tuula A.; Saelens, Xavier; Kainov, Denis
Contributor organization: Institute of Biotechnology
Institute for Molecular Medicine Finland
Denis Kainov / Principal Investigator
Biosciences
Molecular and Translational Virology
General Microbiology
Structure of the Viral Universe
Macromolecular structure and function
Date: 2016-02
Language: eng
Number of pages: 12
Belongs to series: Antiviral Research
ISSN: 0166-3542
DOI: https://doi.org/10.1016/j.antiviral.2015.12.011
URI: http://hdl.handle.net/10138/222918
Abstract: Influenza A viruses (IAVs) impact the public health and global economy by causing yearly epidemics and occasional pandemics. Several anti-IAV drugs are available and many are in development. However, the question remains which of these antiviral agents may allow activation of immune responses and protect patients against co- and re-infections. To answer to this question, we analysed immuno-modulating properties of the antivirals saliphenylhalamide (SaliPhe), SNS-032, obatoclax, and gemcitabine, and found that only gemcitabine did not impair immune responses in infected cells. It also allowed activation of innate immune responses in lipopolysaccharide (LPS)- and interferon alpha (IFN alpha)-stimulated macrophages. Moreover, immuno-mediators produced by gemcitabine-treated IAV-infected macrophages were able to prime immune responses in non-infected cells. Thus, we identified an antiviral agent which might be beneficial for treatment of patients with severe viral infections. (C) 2015 The Authors. Published by Elsevier B.V.
Subject: Influenza A virus
Antiviral agents
Innate immunity
Immune responses
Virus-host interaction
INFLUENZA-A-VIRUS
NS1 PROTEIN
HUMAN MACROPHAGES
RNA-BINDING
NEURAMINIDASE INHIBITORS
PYRIMIDINE BIOSYNTHESIS
ANTIVIRAL RESPONSES
VIRAL-INFECTIONS
EPITHELIAL-CELLS
GENE-EXPRESSION
1183 Plant biology, microbiology, virology
1182 Biochemistry, cell and molecular biology
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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