Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine

Show full item record



Permalink

http://hdl.handle.net/10138/222918

Citation

Soderholm , S , Anastasina , M , Islam , M M , Tynell , J , Poranen , M M , Bamford , D H , Stenman , J , Julkunen , I , Sauliene , I , De Brabander , J K , Matikainen , S , Nyman , T A , Saelens , X & Kainov , D 2016 , ' Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine ' , Antiviral Research , vol. 126 , pp. 69-80 . https://doi.org/10.1016/j.antiviral.2015.12.011

Title: Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine
Author: Soderholm, Sandra; Anastasina, Maria; Islam, Mohammad Majharul; Tynell, Janne; Poranen, Minna M.; Bamford, Dennis H.; Stenman, Jakob; Julkunen, Ilkka; Sauliene, Ingrida; De Brabander, Jef K.; Matikainen, Sampsa; Nyman, Tuula A.; Saelens, Xavier; Kainov, Denis
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Biosciences
University of Helsinki, Institute of Biotechnology
University of Helsinki, Minerva Fdn
University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2016-02
Language: eng
Number of pages: 12
Belongs to series: Antiviral Research
ISSN: 0166-3542
URI: http://hdl.handle.net/10138/222918
Abstract: Influenza A viruses (IAVs) impact the public health and global economy by causing yearly epidemics and occasional pandemics. Several anti-IAV drugs are available and many are in development. However, the question remains which of these antiviral agents may allow activation of immune responses and protect patients against co- and re-infections. To answer to this question, we analysed immuno-modulating properties of the antivirals saliphenylhalamide (SaliPhe), SNS-032, obatoclax, and gemcitabine, and found that only gemcitabine did not impair immune responses in infected cells. It also allowed activation of innate immune responses in lipopolysaccharide (LPS)- and interferon alpha (IFN alpha)-stimulated macrophages. Moreover, immuno-mediators produced by gemcitabine-treated IAV-infected macrophages were able to prime immune responses in non-infected cells. Thus, we identified an antiviral agent which might be beneficial for treatment of patients with severe viral infections. (C) 2015 The Authors. Published by Elsevier B.V.
Subject: Influenza A virus
Antiviral agents
Innate immunity
Immune responses
Virus-host interaction
INFLUENZA-A-VIRUS
NS1 PROTEIN
HUMAN MACROPHAGES
RNA-BINDING
NEURAMINIDASE INHIBITORS
PYRIMIDINE BIOSYNTHESIS
ANTIVIRAL RESPONSES
VIRAL-INFECTIONS
EPITHELIAL-CELLS
GENE-EXPRESSION
1183 Plant biology, microbiology, virology
1182 Biochemistry, cell and molecular biology
3111 Biomedicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0166354215300504_main_1.pdf 2.645Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record