Variants in calcium voltage-gated channel subunit Alpha1 C-gene (CACNA1C) are associated with sleep latency in infants

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Kantojärvi , K , Liuhanen , J , Saarenpää-Heikkilä , O , Satomaa , A-L , Kylliäinen , A , Pölkki , P , Jaatela , J , Toivola , A , Milani , L , Himanen , S-L , Porkka-Heiskanen , T , Paavonen , J & Paunio , T 2017 , ' Variants in calcium voltage-gated channel subunit Alpha1 C-gene (CACNA1C) are associated with sleep latency in infants ' , PLoS One , vol. 12 , no. 8 , 0180652 . https://doi.org/10.1371/journal.pone.0180652

Title: Variants in calcium voltage-gated channel subunit Alpha1 C-gene (CACNA1C) are associated with sleep latency in infants
Author: Kantojärvi, Katri; Liuhanen, Johanna; Saarenpää-Heikkilä, Outi; Satomaa, Anna-Liisa; Kylliäinen, Anneli; Pölkki, Pirjo; Jaatela, Julia; Toivola, Auli; Milani, Lili; Himanen, Sari-Leena; Porkka-Heiskanen, Tarja; Paavonen, Juulia; Paunio, Tiina
Contributor: University of Helsinki, Clinicum
University of Helsinki, University of Helsinki
University of Helsinki, Medicum
University of Helsinki, HUS Children and Adolescents
University of Helsinki, Clinicum
Date: 2017-08-09
Language: eng
Number of pages: 12
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/223344
Abstract: Genetic variants in CACNA1C (calcium voltage-gated channel subunit alpha1 C) are associated with bipolar disorder and schizophrenia where sleep disturbances are common. In an experimental model, Cacna1c has been found to modulate the electrophysiological architecture of sleep. There are strong genetic influences for consolidation of sleep in infancy, but only a few studies have thus far researched the genetic factors underlying the process. We hypothesized that genetic variants in CACNA1C affect the regulation of sleep in early development. Seven variants that were earlier associated (genome-wide significantly) with psychiatric disorders at CACNA1C were selected for analyses. The study sample consists of 1086 infants (520 girls and 566 boys) from the Finnish CHILD-SLEEP birth cohort (geno-typed by Illumina Infinium PsychArray BeadChip). Sleep length, latency, and nightly awakenings were reported by the parents of the infants with a home-delivered questionnaire at 8 months of age. The genetic influence of CACNA1C variants on sleep in infants was examined by using PLINK software. Three of the examined CACNA1C variants, rs4765913, rs4765914, and rs2239063, were associated with sleep latency (permuted P
Subject: GENOME-WIDE ASSOCIATION
BIPOLAR DISORDER
AMYGDALA STRUCTURE
CA2+ CHANNELS
DURATION
CONSORTIUM
SCHIZOPHRENIA
METAANALYSIS
POPULATION
CHILDREN
3124 Neurology and psychiatry
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