Vitamin C supplementation and common cold symptoms: factors affecting the magnitude of the benefit

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dc.contributor University of Helsinki, Department of Public Health en Hemilä, Harri 2017-09-13T21:22:00Z 2017-09-13T21:22:00Z 1999
dc.identifier.citation Hemilä , H 1999 , ' Vitamin C supplementation and common cold symptoms: factors affecting the magnitude of the benefit ' , Medical Hypotheses , vol. 52 , no. 2 , pp. 171-178 . en
dc.identifier.issn 0306-9877
dc.identifier.other PURE: 8113606
dc.identifier.other PURE UUID: c07badeb-c043-4bb5-8aa7-29b735ba835f
dc.identifier.other WOS: 000079688900012
dc.identifier.other Scopus: 0033081257
dc.identifier.other ORCID: /0000-0002-4710-307X/work/49696018
dc.description.abstract Placebo-controlled trials have shown that vitamin C supplementation decreases the duration and severity of common cold infections. However, the magnitude of the benefit has substantially varied, hampering conclusions about the clinical significance of the vitamin. In this paper, 23 studies with regular vitamin C supplementation (> or = 1 g/day) were analyzed to find out factors that may explain some part of the variation in the results. It was found that on average, vitamin C produces greater benefit for children than for adults. The dose may also affect the magnitude of the benefit, there being on average greater benefit from > or = 2 g/day compared to 1 g/day of the vitamin. In five studies with adults administered 1 g/day of vitamin C, the median decrease in cold duration was only 6%, whereas in two studies with children administered 2 g/day the median decrease was four times higher, 26%. The trials analyzed in this work used regular vitamin C supplementation, but it is conceivable that therapeutic supplementation starting early at the onset of the cold episode could produce comparable benefits. Since few trials have examined the effects of therapeutic supplementation and their results have been variable, further therapeutic trials are required to examine the role of vitamin C in the treatment of colds. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Medical Hypotheses
dc.rights en
dc.subject ASCORBIC-ACID en
dc.subject PROPHYLAXIS en
dc.subject SCHOOLCHILDREN en
dc.subject ILLNESS en
dc.subject TRIAL en
dc.subject 314 Health sciences en
dc.title Vitamin C supplementation and common cold symptoms: factors affecting the magnitude of the benefit en
dc.type Article
dc.description.version Peer reviewed
dc.description.version Peer reviewed
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/acceptedVersion
dc.type.uri info:eu-repo/semantics/publishedVersion

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