Innate and adaptive immunity in the development of depression: : An update on current knowledge and technological advances

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http://hdl.handle.net/10138/223777

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Haapakoski , R , Ebmeier , K P , Alenius , H & Kivimäki , M 2016 , ' Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances ' , Progress in Neuro-Psychopharmacology & Biological Psychiatry , vol. 66 , pp. 63-72 . https://doi.org/10.1016/j.pnpbp.2015.11.012

Title: Innate and adaptive immunity in the development of depression: : An update on current knowledge and technological advances
Author: Haapakoski, Rita; Ebmeier, Klaus P.; Alenius, Harri; Kivimäki, Mika
Contributor: University of Helsinki, Clinicum
Date: 2016
Language: eng
Number of pages: 10
Belongs to series: Progress in Neuro-Psychopharmacology & Biological Psychiatry
ISSN: 0278-5846
URI: http://hdl.handle.net/10138/223777
Abstract: The inflammation theory of depression, proposed over 20years ago, was influenced by early studies on T cell responses and since then has been a stimulus for numerous research projects aimed at understanding the relationship between immune function and depression. Observational studies have shown that indicators of immunity, especially C reactive protein and proinflammatory cytokines, such as interleukin 6, are associated with an increased risk of depressive disorders, although the evidence from randomized trials remains limited and only few studies have assessed the interplay between innate and adaptive immunity in depression. In this paper, we review current knowledge on the interactions between central and peripheral innate and adaptive immune molecules and the potential role of immune-related activation of microglia, inflammasomes and indoleamine-2,3-dioxygenase in the development of depressive symptoms. We highlight how combining basic immune methods with more advanced 'omics' technologies would help us to make progress in unravelling the complex associations between altered immune function and depressive disorders, in the identification of depression-specific biomarkers and in developing immunotherapeutic treatment strategies that take individual variability into account.
Subject: 3142 Public health care science, environmental and occupational health
depression
inflammation
cytokine
innate immunity
adaptive immunity
omics tecnologies
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