Development of a Novel Electrospun Nanofibrous Delivery System for Poorly Water-Soluble ß-Sitosterol

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Paaver , U , Laidmäe , I , Almeida Santos , H , Yliruusi , J K , Aruväli , J , Kogermann , K & Heinämäki , J T 2016 , ' Development of a Novel Electrospun Nanofibrous Delivery System for Poorly Water-Soluble ß-Sitosterol ' , Asian Journal of Pharmaceutical Sciences , vol. 11 , no. 4 , pp. 500–506 . https://doi.org/10.1016/j.ajps.2016.04.005

Title: Development of a Novel Electrospun Nanofibrous Delivery System for Poorly Water-Soluble ß-Sitosterol
Author: Paaver, Urve; Laidmäe, Ivo; Almeida Santos, Helder; Yliruusi, Jouko Kalervo; Aruväli, Jaan; Kogermann, Karin; Heinämäki, Jyrki Tapio
Contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
Date: 2016-08
Language: eng
Number of pages: 7
Belongs to series: Asian Journal of Pharmaceutical Sciences
ISSN: 1818-0876
URI: http://hdl.handle.net/10138/223784
Abstract: Electrospinning was used as a novel technique for fabricating polymeric nanofibers of a serum cholesterol lowering and poorly water-soluble plant sterol, β-sitosterol. Chitosan was used as a stabilizer/carrier polymer. The mean diameters of nanofibers ranged from 150 nm to 218 nm. β-sitosterol was in an amorphous form and homogeneously dispersed in the nanofibers. The β-sitosterol-loaded nanofibers were freely water-soluble and exhibited very short lag-time in releasing the plant sterol. The dissolution was associated with an immediate recrystallization of β-sitosterol in submicron level. In conclusion, electrospinning is a promising future technology for the formulation of poorly water-soluble plant sterols.
Subject: 317 Pharmacy
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