Biomarkers and prediction of myocardial triglyceride content in non-diabetic men

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Graner , M , Gustavsson , S , Nyman , K , Siren , R , Pentikainen , M O , Lundbom , J , Hakkarainen , A , Lauerma , K , Lundbom , N , Boren , J , Nieminen , M S & Taskinen , M -R 2016 , ' Biomarkers and prediction of myocardial triglyceride content in non-diabetic men ' , Nutrition, Metabolism and Cardiovascular Diseases , vol. 26 , no. 2 , pp. 134-140 . https://doi.org/10.1016/j.numecd.2015.11.002

Title: Biomarkers and prediction of myocardial triglyceride content in non-diabetic men
Author: Graner, M.; Gustavsson, S.; Nyman, Kristofer; Siren, R.; Pentikainen, M. O.; Lundbom, J.; Hakkarainen, A.; Lauerma, K.; Lundbom, N.; Boren, J.; Nieminen, M. S.; Taskinen, M. -R.
Other contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Clinicum
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Research Programs Unit







Date: 2016-02
Language: eng
Number of pages: 7
Belongs to series: Nutrition, Metabolism and Cardiovascular Diseases
ISSN: 0939-4753
DOI: https://doi.org/10.1016/j.numecd.2015.11.002
URI: http://hdl.handle.net/10138/223889
Abstract: Background and aims: Lipid oversupply to cardiomyocytes or decreased utilization of lipids leads to cardiac steatosis. We aimed to examine the role of different circulating metabolic biomarkers as predictors of myocardial triglyceride (TG) content in non-diabetic men. Methods and results: Myocardial and hepatic TG contents were measured with 1.5 T magnetic resonance (MR) spectroscopy, and LV function, visceral adipose tissue (VAT), abdominal subcutaneous tissue (SAT), epicardial and pericardial fat by MR imaging in 76 non-diabetic men. Serum concentration of circulating metabolic biomarkers [adiponectin, leptin, adipocyte-fatty acid binding protein 4 (A-FABP 4), resistin, and lipocalin-2] including beta-hydroxybuturate (beta-OHB) were measured. Subjects were stratified by tertiles of myocardial TG into low, moderate, and high myocardial TG content groups. Concentrations of beta-OHB were lower (p = 0.003) and serum levels of A-FABP 4 were higher (p <0.001) in the group with high myocardial TG content compared with the group with low myocardial TG content. beta-OHB was negatively correlated with myocardial TG content (r = -0.316, p = 0.006), whereas A-FABP 4 was not correlated with myocardial TG content (r = 0.192, p = 0.103). In multivariable analyses beta-OHB and plasma glucose levels were the best predictors of myocardial TG content independently of VAT and hepatic TG content. The model explained 58.8% of the variance in myocardial TG content. Conclusion: Our data showed that beta-OHB and fasting glucose were the best predictors of myocardial TG content in non-diabetic men. These data suggest that hyperglycemia and alterations in lipid oxidation may be associated with cardiac steatosis in humans. (C) 2015 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
Subject: Myocardial triglyceride content
beta-hydroxybuturate
Biomarkers
TYPE-2 DIABETES-MELLITUS
KETONE-BODY METABOLISM
CARDIOVASCULAR-DISEASE
INDEPENDENT PREDICTOR
INSULIN SENSITIVITY
CARDIAC STEATOSIS
VISCERAL OBESITY
FAT ACCUMULATION
ADIPOSE-TISSUE
ADIPONECTIN
3121 General medicine, internal medicine and other clinical medicine
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