Incidence of cancer among grand multiparous women in Finland with special focus on non-gynaecological cancers : A population-based cohort study

Show full item record



Permalink

http://hdl.handle.net/10138/223902

Citation

Högnäs , E , Kauppila , A , Hinkula , M , Tapanainen , J S & Pukkala , E 2016 , ' Incidence of cancer among grand multiparous women in Finland with special focus on non-gynaecological cancers : A population-based cohort study ' , Acta Oncologica , vol. 55 , no. 3 , pp. 370-376 . https://doi.org/10.3109/0284186X.2015.1063775

Title: Incidence of cancer among grand multiparous women in Finland with special focus on non-gynaecological cancers : A population-based cohort study
Author: Högnäs, Emma; Kauppila, Antti; Hinkula, Marianne; Tapanainen, Juha S.; Pukkala, Eero
Contributor: University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Clinicum
Date: 2016-03-03
Language: eng
Number of pages: 7
Belongs to series: Acta Oncologica
ISSN: 0284-186X
URI: http://hdl.handle.net/10138/223902
Abstract: Background. Many studies have previously revealed evidence of an association between grand multiparity (five or more deliveries) and gynaecological cancer. Oestrogen has an impact on cancer formation and the amount of circulating oestrogen is significantly higher during pregnancy. Also the lifestyle of grand multiparous women differs somewhat from the average population. Considering these factors it is plausible that also non-gynaecological cancers are associated with multiparity. The aim of our study was to determine cancer incidence among grand multiparous women, with special attention to non-gynaecological cancers. Material and methods. All 102 541 women alive in 1974-2011 and having had at least five deliveries were identified in the Finnish Population Register and followed up for cancer incidence through the Finnish Cancer Registry to the end of 2011. Standardised incidence ratios (SIRs) were defined as ratios between observed and expected numbers of cases, the latter ones based on incidence in the entire Finnish female population. Results. The overall incidence of non-gynaecological cancers was the same as in the reference population (SIR 0.98, 95% confidence interval 0.90-1.06). The incidence of cancers of the gall-bladder (SIR 1.42, 1.26-1.58), biliary tract (1.19, 1.04-1.35) and kidney (1.22, 1.14-1.31) was increased. There were significantly fewer cases than expected of urinary bladder cancer (SIR 0.70, 0.61-0.78), lung cancer (0.87, 0.81-0.92), colon cancer (0.94, 0.89-0.99) and all types of skin cancers. As a consequence of the decreased incidence of gynaecological cancers (SIR 0.74, 0.71-0.77) and breast cancer (0.60, 0.58-0.61), the SIR for cancer overall was 0.84 (0.83-0.85). Conclusion. The study demonstrated that grand multiparous women have a similar overall risk of non-gynaecological cancers as other women, despite significant differences in some specific forms of cancer.
Subject: RENAL-CELL CANCER
REPRODUCTIVE FACTORS
THYROID-CANCER
COLORECTAL-CANCER
POSTMENOPAUSAL WOMEN
HORMONAL FACTORS
POOLED ANALYSIS
BREAST-CANCER
1ST BIRTH
RISK
3122 Cancers
3123 Gynaecology and paediatrics
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Incidence_of_cancer_among_grand_multiparous.pdf 541.0Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record