Gestational Exposure to Selective Serotonin Reuptake Inhibitors and Offspring Psychiatric Disorders : A National Register-Based Study

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dc.contributor.author Malm, Heli
dc.contributor.author Brown, Alan S.
dc.contributor.author Gissler, Mika
dc.contributor.author Gyllenberg, David
dc.contributor.author Hinkka-Yli-Salomaki, Susanna
dc.contributor.author McKeague, Ian W.
dc.contributor.author Weissman, Myrna
dc.contributor.author Wickramaratne, Priya
dc.contributor.author Artama, Miia
dc.contributor.author Gingrich, Jay A.
dc.contributor.author Sourander, Andre
dc.date.accessioned 2017-09-14T09:53:03Z
dc.date.available 2021-12-17T18:46:42Z
dc.date.issued 2016-05
dc.identifier.citation Malm , H , Brown , A S , Gissler , M , Gyllenberg , D , Hinkka-Yli-Salomaki , S , McKeague , I W , Weissman , M , Wickramaratne , P , Artama , M , Gingrich , J A & Sourander , A 2016 , ' Gestational Exposure to Selective Serotonin Reuptake Inhibitors and Offspring Psychiatric Disorders : A National Register-Based Study ' , Journal of the American Academy of Child and Adolescent Psychiatry , vol. 55 , no. 5 , pp. 359-366 . https://doi.org/10.1016/j.jaac.2016.02.013
dc.identifier.other PURE: 64215489
dc.identifier.other PURE UUID: 6d3af157-009e-42d6-8c12-fa3dc1ebc026
dc.identifier.other WOS: 000375363100007
dc.identifier.other Scopus: 84961777347
dc.identifier.uri http://hdl.handle.net/10138/223956
dc.description.abstract Objective: To investigate the impact of gestational exposure to selective serotonin reuptake inhibitors (SSRIs) on offspring neurodevelopment. Method: This is a cohort study using national register data in Finland between the years 1996 and 2010. Pregnant women and their offspring were categorized into 4 groups: SSRI exposed (n = 15,729); exposed to psychiatric disorder, no antidepressants (n = 9,651); exposed to SSRIs only before pregnancy (n = 7,980); and unexposed to antidepressants and psychiatric disorders (n = 31,394). We investigated the cumulative incidence of offspring diagnoses of depression, anxiety, autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD) for the 4 groups from birth to 14 years, adjusting for confounders. Results: The cumulative incidence of depression among offspring exposed prenatally to SSRIs was 8.2% (95% CI = 3.1-13.3%) by age 14.9 years, compared with 1.9% (95% CI = 0.9-2.9%) in the psychiatric disorder, no medication group (adjusted hazard ratio [HR] = 1.78; 95% CI = 1.12-2.82; p=.02) and to 2.8% (95% CI = 1.4-4.3%) in the SSRI discontinued group (HR = 1.84; 95% CI = 1.14-2.97; p=.01). Rates of anxiety, ASD, and ADHD diagnoses were comparable to rates in offspring of mothers with a psychiatric disorder but no medication during pregnancy. Comparing SSRI exposed to unexposed individuals, the HRs were significantly elevated for each outcome. Conclusion: Prenatal SSRI exposure was associated with increased rates of depression diagnoses in early adolescence but not with ASD or ADHD. Until confirmed, these findings must be balanced against the substantial adverse consequences of untreated maternal depression. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Journal of the American Academy of Child and Adolescent Psychiatry
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject SSRI
dc.subject pregnancy
dc.subject offspring depression
dc.subject ASD
dc.subject ADHD
dc.subject AUTISM SPECTRUM DISORDER
dc.subject ANTIDEPRESSANT USE
dc.subject MATERNAL DEPRESSION
dc.subject PRENATAL EXPOSURE
dc.subject PREGNANCY
dc.subject RISK
dc.subject CHILDREN
dc.subject BEHAVIORS
dc.subject QUALITY
dc.subject WOMEN
dc.subject 3124 Neurology and psychiatry
dc.subject 515 Psychology
dc.title Gestational Exposure to Selective Serotonin Reuptake Inhibitors and Offspring Psychiatric Disorders : A National Register-Based Study en
dc.type Article
dc.contributor.organization Department of Clinical Pharmacology
dc.contributor.organization Medicum
dc.contributor.organization Clinicum
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.jaac.2016.02.013
dc.relation.issn 0890-8567
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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