Venous thromboembolismafter surgical treatment of non-spinal skeletal metastases : An underdiagnosed complication

Show full item record



Permalink

http://hdl.handle.net/10138/223962

Citation

Ratasvuori , M , Lassila , R & Laitinen , M 2016 , ' Venous thromboembolismafter surgical treatment of non-spinal skeletal metastases : An underdiagnosed complication ' , Thrombosis Research , vol. 141 , pp. 124-128 . https://doi.org/10.1016/j.thromres.2016.03.013

Title: Venous thromboembolismafter surgical treatment of non-spinal skeletal metastases : An underdiagnosed complication
Author: Ratasvuori, Maire; Lassila, Riitta; Laitinen, Minna
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Tampere University Hospital (TAYS)
Date: 2016-05
Language: eng
Number of pages: 5
Belongs to series: Thrombosis Research
ISSN: 0049-3848
URI: http://hdl.handle.net/10138/223962
Abstract: Introduction and aim: Venous thromboembolism (VTE) is a severe complication associated both with major orthopaedic surgery and cancer. However, survival and postoperative complications of skeletal metastases despite their thrombogenic potential, have received little attention in both the clinical management and research setting. This single-centre observational cohort study aimed to evaluate the incidence and impact of VTE in association with cancer surgery targeted to the management of fractures secondary to skeletal metastases. Methods: Data were collected retrospectively from the medical database. We included consecutive 306 patients operated for 343 non-spinal skeletal metastases during a 15-year period (1999-2014). The incidence of VTE and its risk factors were assessed using binary logistic regression analysis. Kaplan-Meier and Cox regression analyses were used to evaluate variables affecting survival. Results: The rate of symptomatic VTE was 10% (30/306) during the 3-month postoperative period, while 79% received thromboprophylaxis. Fatal pulmonary embolism (PE) rate was high, 3.3% (10/306) after surgery. Intraoperative oxygen saturation drop, pulmonary metastases and intramedullary nailing were independent risk factors for VTE. Indicators of decreased survival were lung cancer, intramedullary nailing, multiple skeletal and pulmonary metastases, anaemia, leukocytosis, and PE. Conclusion: Relationship between fractures secondary to skeletal metastases and VTE needs further clinical attention. Whether the survival of patients with fractures secondary to skeletal metastases can be improved by targeted thromboprophylactic means should be studied further. (C) 2016 Elsevier Ltd. All rights reserved.
Subject: Metastasis
Orthopaedic surgery
Venous thromboembolism
Pulmonary embolism
Survival
PULMONARY-EMBOLISM
CANCER-PATIENTS
RISK-FACTORS
JOINT REPLACEMENT
MAJOR TRAUMA
THROMBOSIS
SURGERY
CHEMOTHERAPY
PROPHYLAXIS
MALIGNANCY
3121 General medicine, internal medicine and other clinical medicine
3126 Surgery, anesthesiology, intensive care, radiology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0049384816300731_main.pdf 256.9Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record