ASSOCIATION OF LONG-TERM DIETARY FAT INTAKE, EXERCISE, AND WEIGHT WITH LATER COGNITIVE FUNCTION IN THE FINNISH DIABETES PREVENTION STUDY

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Lehtisalo , J , Lindstrom , J , Ngandu , T , Kivipelto , M , Ahtiluoto , S , Ilanne-Parikka , P , Keinanen-Kiukaanniemi , S , Eriksson , J G , Uusitupa , M , Tuomilehto , J , Luchsinger , J & Finnish Diabet Prevention Study DP 2016 , ' ASSOCIATION OF LONG-TERM DIETARY FAT INTAKE, EXERCISE, AND WEIGHT WITH LATER COGNITIVE FUNCTION IN THE FINNISH DIABETES PREVENTION STUDY ' , Journal of nutrition, health & aging , vol. 20 , no. 2 , pp. 146-154 . https://doi.org/10.1007/s12603-015-0565-1

Title: ASSOCIATION OF LONG-TERM DIETARY FAT INTAKE, EXERCISE, AND WEIGHT WITH LATER COGNITIVE FUNCTION IN THE FINNISH DIABETES PREVENTION STUDY
Author: Lehtisalo, J.; Lindstrom, J.; Ngandu, T.; Kivipelto, M.; Ahtiluoto, S.; Ilanne-Parikka, P.; Keinanen-Kiukaanniemi, S.; Eriksson, J. G.; Uusitupa, M.; Tuomilehto, J.; Luchsinger, J.; Finnish Diabet Prevention Study DP
Contributor: University of Helsinki, Department of Public Health
University of Helsinki, Clinicum
Date: 2016-02
Language: eng
Number of pages: 9
Belongs to series: Journal of nutrition, health & aging
ISSN: 1279-7707
URI: http://hdl.handle.net/10138/224001
Abstract: Objectives: To investigate associations of long-term nutrient intake, physical activity and obesity with later cognitive function among the participants in the Finnish Diabetes Prevention Study, in which a lifestyle intervention was successful in diabetes prevention. Design: An active lifestyle intervention phase during middle age (mean duration 4 years) and extended follow-up (additional 9 years) with annual lifestyle measurements, followed by an ancillary cognition assessment. Setting: 5 research centers in Finland. Participants: Of the 522 middle-aged, overweight participants with impaired glucose tolerance recruited to the study, 364 (70%) participated in the cognition assessment (mean age 68 years). Measurements: A cognitive assessment was executed with the CERAD test battery and the Trail Making Test A on average 13 years after baseline. Lifestyle measurements included annual clinical measurements, food records, and exercise questionnaires during both the intervention and follow-up phase. Results: Lower intake of total fat (p=0.021) and saturated fatty acids (p=0.010), and frequent physical activity (p=0.040) during the whole study period were associated with better cognitive performance. Higher BMI (p= 0.012) and waist circumference (p= 0.012) were also associated with worse performance, but weight reduction prior to the cognition assessment predicted worse performance as well (decrease vs. increase, p= 0.008 for BMI and p= 0.002 for waist). Conclusions: Long-term dietary fat intake, BMI, and waist circumference have an inverse association with cognitive function in later life among people with IGT. However, decreases in BMI and waist prior to cognitive assessment are associated with worse cognitive performance, which could be explained by reverse causality.
Subject: Cognition
diet
weight
prevention
VASCULAR RISK-FACTORS
ALZHEIMERS-DISEASE
PHYSICAL-ACTIVITY
IMPROVES COGNITION
MEDITERRANEAN DIET
AEROBIC EXERCISE
OLDER-ADULTS
LIFE-STYLE
FOLLOW-UP
WOMEN
3121 General medicine, internal medicine and other clinical medicine
3142 Public health care science, environmental and occupational health
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