Oxygen deteriorates arterial function in type 1 diabetes

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Gordin , D , Bernardi , L , Rosengård-Bärlund , M , Makinen , V-P , Soro-Paavonen , A , Forsblom , C , Sandelin , A & Groop , P-H 2016 , ' Oxygen deteriorates arterial function in type 1 diabetes ' , Acta Diabetologica , vol. 53 , no. 3 , pp. 349-357 . https://doi.org/10.1007/s00592-015-0775-3

Title: Oxygen deteriorates arterial function in type 1 diabetes
Author: Gordin, Daniel; Bernardi, Luciano; Rosengård-Bärlund, Milla; Makinen, Ville-Petteri; Soro-Paavonen, Aino; Forsblom, Carol; Sandelin, Anna; Groop, Per-Henrik
Other contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Medical and Clinical Genetics
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum







Date: 2016-06
Language: eng
Number of pages: 9
Belongs to series: Acta Diabetologica
ISSN: 0940-5429
DOI: https://doi.org/10.1007/s00592-015-0775-3
URI: http://hdl.handle.net/10138/224045
Abstract: Aims Although oxygen is commonly used to treat various medical conditions, it has recently been shown to worsen vascular function (arterial stiffness) in healthy volunteers and even more in patients in whom vascular function might already be impaired. The effects of oxygen on arterial function in patients with type 1 diabetes (T1D) are unknown, although such patients display disturbed vascular function already at rest. Therefore, we tested whether short-term oxygen administration may alter the arterial function in patients with T1D. Methods We estimated arterial stiffness by augmentation index (AIx) and the pulse wave velocity equivalent (SI-DVP) in 98 patients with T1D and 49 age-and sex-matched controls at baseline and during hyperoxia by obtaining continuous noninvasive finger pressure waveforms using a recently validated method. Results AIx and SI-DVP increased in patients (P <0.05) but not in controls in response to hyperoxia. The increase in AIx (P = 0.05), systolic (P <0.05), and diastolic (P <0.05) blood pressure was higher in the patients than in the controls. Conclusions Short-term oxygen administration deteriorates arterial function in patients with T1D compared to non-diabetic control subjects. Since disturbed arterial function plays a major role in the development of diabetic complications, these findings may be of clinical relevance.
Subject: Augmentation index
Blood pressure
Hyperoxia
Oxygen
Pulse wave velocity
Type 1 diabetes
CARDIOVASCULAR EVENTS
VASCULAR REACTIVITY
BLOOD-PRESSURE
HYPEROXIA
STIFFNESS
METABOLISM
DISEASE
COMPLICATIONS
HEMODYNAMICS
MORTALITY
3121 General medicine, internal medicine and other clinical medicine
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