Optimal digital filters for analyzing the mid-latency auditory P50 event-related potential in patients with Alzheimer's disease

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http://hdl.handle.net/10138/224052

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Liljander , S , Holm , A , Keski-Säntti , P & Partanen , J V 2016 , ' Optimal digital filters for analyzing the mid-latency auditory P50 event-related potential in patients with Alzheimer's disease ' , Journal of Neuroscience Methods , vol. 266 , pp. 50-67 . https://doi.org/10.1016/j.jneumeth.2016.03.013

Title: Optimal digital filters for analyzing the mid-latency auditory P50 event-related potential in patients with Alzheimer's disease
Author: Liljander, Sara; Holm, Anu; Keski-Säntti, Petra; Partanen, Juhani V.
Contributor: University of Helsinki, Neurologian yksikkö
University of Helsinki, Department of Neurosciences
Date: 2016-06-15
Language: eng
Number of pages: 18
Belongs to series: Journal of Neuroscience Methods
ISSN: 0165-0270
URI: http://hdl.handle.net/10138/224052
Abstract: Background: Filtering is an effective pre-processing technique for improving the signal-to-noise ratio of ERP waveforms. Filters can, however, introduce substantial distortions into the time-domain representations of ERP waveforms. Inappropriate filter parameters may lead to the presence of statistically significant but artificial effects, whereas true effects may appear as insignificant. New method: The present study aimed to determine the optimal digital filters for analyzing the auditory P50 component in patients with Alzheimer's disease. To provide evidence of the optimal filter settings, different high-pass and low-pass filters were applied to ERP waveforms obtained from a conditioning testing paradigm. The results facilitate practical recommendations for selection of filters that maximize the signal-to-noise ratio of the P50 components without introducing significant distortions. Results: The present study confirms that filter parameters have a significant effect on the amplitude and gating measures of the P50 component. Setting the high-pass cut-off at 0.1 Hz and the low-pass cut-off at 90Hz (or above) is recommended for P50 component analyses. Comparison with existing methods: The majority of ERP studies on sensory gating report using high-pass filters with 10-Hz cut-offs to measure P50 suppression. Such a high cut-off appeared to induce significant distortions into the ERP waveforms; thus, the authors advise against using these excessive high-pass cut-offs. Conclusions: Filtering broadband signals, such as ERP signals, necessary results in time-domain distortions. However, by adjusting the filter parameters carefully according to the components of interest, it is possible to minimize filter artifacts and obtain more easily interpretable ERP waveforms. (C) 2016 Elsevier B.V. All rights reserved.
Subject: Event-related potential
P50
Sensory gating
Alzheimer's disease
Digital filter
Filter distortion
GATING DEFICIT
ELECTROPHYSIOLOGICAL DATA
EVOKED-POTENTIALS
EEG DYNAMICS
SCHIZOPHRENIA
ERP
SUPPRESSION
NEGATIVITY
COGNITION
ADULTS
3112 Neurosciences
3124 Neurology and psychiatry
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