Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics

Show full item record



Permalink

http://hdl.handle.net/10138/224060

Citation

Karkkainen , O , Hakkinen , M R , Auriola , S , Kautiainen , H , Tiihonen , J & Storvik , M 2016 , ' Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics ' , Alcohol (New York) , vol. 52 , pp. 63-70 . https://doi.org/10.1016/j.alcohol.2016.03.002

Title: Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics
Author: Karkkainen, Olli; Hakkinen, Merja R.; Auriola, Seppo; Kautiainen, Hannu; Tiihonen, Jari; Storvik, Markus
Contributor: University of Helsinki, Department of General Practice and Primary Health Care
Date: 2016-05
Language: eng
Number of pages: 8
Belongs to series: Alcohol (New York)
ISSN: 0741-8329
URI: http://hdl.handle.net/10138/224060
Abstract: Intra-tissue levels of steroid hormones (e.g., dehydroepiandrosterone [DHEA], pregnenolone [PREGN], and testosterone [T]) may influence the pathological changes seen in neurotransmitter systems of alcoholic brains. Our aim was to compare levels of these steroid hormones between the post-mortem brain samples of alcoholics and non-alcoholic controls. We studied steroid levels with quantitative liquid chromatography tandem mass spectrometry (LC-MS/MS) in post-mortem brain samples of alcoholics (N = 14) and non-alcoholic controls (N = 10). Significant differences were observed between study groups in DHEA and PREGN levels (p values 0.0056 and 0.019, respectively), but not in T levels. Differences between the study groups were most prominent in the nucleus accumbens (NAC), anterior cingulate cortex (ACC), and anterior insula (AINS). DHEA levels were increased in most alcoholic subjects compared to controls. However, only a subgroup of alcoholics showed increased PREGN levels. Negative Spearman correlations between tissue levels of PREGN and previous reports of [H-3]naloxone binding to mu-opioid receptors were observed in the AINS, ACC, NAC, and frontal cortex (R values between -0.6 and -.8; p values
Subject: DHEA
Pregnenolone
Testosterone
Anterior cingulate cortex
Anterior insula
mu-opioid receptor
WHOLE-HEMISPHERE AUTORADIOGRAPHY
PITUITARY-ADRENAL AXIS
GAMMA-AMINOBUTYRIC-ACID
PREFERRING P RATS
GABA-A RECEPTOR
CLONINGER TYPE-1
ENDOGENOUS CANNABINOIDS
ADMINISTERED ETHANOL
CYNOMOLGUS MONKEYS
ION CURRENT
3142 Public health care science, environmental and occupational health
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0741832915300951_main.pdf 779.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record