Electroretinography and Visual Evoked Potentials in Childhood Brain Tumor Survivors

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http://hdl.handle.net/10138/224074

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Pietila , S , Lenko , H L , Oja , S , Koivisto , A-M , Pietila , T & Mäkipernaa , A M-T 2016 , ' Electroretinography and Visual Evoked Potentials in Childhood Brain Tumor Survivors ' , Journal of Child Neurology , vol. 31 , no. 8 , pp. 998-1004 . https://doi.org/10.1177/0883073816634863

Title: Electroretinography and Visual Evoked Potentials in Childhood Brain Tumor Survivors
Author: Pietila, Sari; Lenko, Hanna L.; Oja, Sakari; Koivisto, Anna-Maija; Pietila, Timo; Mäkipernaa, Anne Marja-Terttu
Contributor: University of Helsinki, Hematologian yksikkö
Date: 2016-07
Language: eng
Number of pages: 7
Belongs to series: Journal of Child Neurology
ISSN: 0883-0738
URI: http://hdl.handle.net/10138/224074
Abstract: This population-based cross-sectional study evaluates the clinical value of electroretinography and visual evoked potentials in childhood brain tumor survivors. A flash electroretinography and a checkerboard reversal pattern visual evoked potential (or alternatively a flash visual evoked potential) were done for 51 survivors (age 3.8-28.7 years) after a mean follow-up time of 7.6 (1.5-15.1) years. Abnormal electroretinography was obtained in 1 case, bilaterally delayed abnormal visual evoked potentials in 22/51 (43%) cases. Nine of 25 patients with infratentorial tumor location, and altogether 12 out of 31 (39%) patients who did not have tumors involving the visual pathways, had abnormal visual evoked potentials. Abnormal electroretinographies are rarely observed, but abnormal visual evoked potentials are common even without evident anatomic lesions in the visual pathway. Bilateral changes suggest a general and possibly multifactorial toxic/adverse effect on the visual pathway. Electroretinography and visual evoked potential may have clinical and scientific value while evaluating long-term effects of childhood brain tumors and tumor treatment.
Subject: brain tumor
childhood
late effects
visual evoked potentials
electroretinography
MULTIPLE-SCLEROSIS
RADIATION-THERAPY
CISPLATIN THERAPY
RETINAL TOXICITY
OPTIC NEUROPATHY
CHILDREN
COMPLICATIONS
PATHWAY
CHEMOTHERAPY
CARBOPLATIN
3123 Gynaecology and paediatrics
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