Association Between Fecal Calprotectin Levels and Small-bowel Inflammation Score in Capsule Endoscopy : A Multicenter Retrospective Study

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Koulaouzidis , A , Sipponen , T , Nemeth , A , Makins , R , Kopylov , U , Nadler , M , Giannakou , A , Yung , D E , Johansson , G W , Bartzis , L , Thorlacius , H , Seidman , E G , Eliakim , R , Plevris , J N & Toth , E 2016 , ' Association Between Fecal Calprotectin Levels and Small-bowel Inflammation Score in Capsule Endoscopy : A Multicenter Retrospective Study ' , Digestive Diseases and Sciences , vol. 61 , no. 7 , pp. 2033-2040 . https://doi.org/10.1007/s10620-016-4104-7

Title: Association Between Fecal Calprotectin Levels and Small-bowel Inflammation Score in Capsule Endoscopy : A Multicenter Retrospective Study
Author: Koulaouzidis, Anastasios; Sipponen, Taina; Nemeth, Artur; Makins, Richard; Kopylov, Uri; Nadler, Moshe; Giannakou, Andry; Yung, Diana E.; Johansson, Gabriele Wurm; Bartzis, Leonidas; Thorlacius, Henrik; Seidman, Ernest G.; Eliakim, Rami; Plevris, John N.; Toth, Ervin
Other contributor: University of Helsinki, Gastroenterologian yksikkö


Date: 2016-07
Language: eng
Number of pages: 8
Belongs to series: Digestive Diseases and Sciences
ISSN: 0163-2116
DOI: https://doi.org/10.1007/s10620-016-4104-7
URI: http://hdl.handle.net/10138/224099
Abstract: Accurate inflammation reporting in capsule endoscopy (CE) is important for diagnosis and monitoring of treatment of inflammatory bowel disease (IBD). Fecal calprotectin (FC) is a highly specific biomarker of gut inflammation. Lewis score (LS) was developed to standardize quantification of inflammation in small-bowel (SB) CE images. Multicenter retrospective study aiming to investigate correlation between LS and FC in a large group of patients undergoing CE for suspected or known small-bowel IBD, and to develop a model for prediction of CE results (LS) based on FC levels. Five academic centers and a district general hospital offering CE in UK, Finland, Sweden, Canada, and Israel. In total, 333 patients were recruited. They had small-bowel CE and FC done within 3 months. Overall, correlation between FC and LS was weak (r (s): 0.232, P <0.001). When two clinically significant FC thresholds (100 and 250 mu g/g) were examined, the r (s) between FC and LS was 0.247 (weak) and 0.337 (moderate), respectively (P = 0.307). For clinically significant (LS a parts per thousand yen 135) or negative (LS <135) for SB inflammation, ROC curves gave an optimum cutoff point of FC 76 mu g/g with sensitivity 0.59 and specificity 0.41. Limitations: Retrospective design. LS appears to show low correlation with FC as well as other serology markers of inflammation. FC does not appear to be a reliable biomarker for significant small-bowel inflammation. Nevertheless, FC level a parts per thousand yen 76 mu g/g may be associated with appreciable visual inflammation on small-bowel CE in patients with negative prior diagnostic workup.
Subject: Capsule endoscopy
Fecal calprotectin
Lewis score
Small-bowel inflammation
Monocyte count
C-reactive protein
Multicenter study
CROHNS-DISEASE ACTIVITY
ACTIVE ULCERATIVE-COLITIS
ACTIVITY INDEX CECDAI
LEWIS SCORE
VALIDATION
BIOMARKERS
MARKER
METAANALYSIS
VARIABILITY
DIAGNOSIS
3121 General medicine, internal medicine and other clinical medicine
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