Reproducibility of Tract-based and Region-of-Interest DTI Analysis of Long Association Tracts

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http://hdl.handle.net/10138/224104

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Brandstack , N , Kurki , T , Laalo , J , Kauko , T & Tenovuo , O 2016 , ' Reproducibility of Tract-based and Region-of-Interest DTI Analysis of Long Association Tracts ' , Clinical Neuroradiology , vol. 26 , no. 2 , pp. 199-208 . https://doi.org/10.1007/s00062-014-0349-8

Title: Reproducibility of Tract-based and Region-of-Interest DTI Analysis of Long Association Tracts
Author: Brandstack, Nina; Kurki, T.; Laalo, J.; Kauko, T.; Tenovuo, O.
Contributor organization: Department of Diagnostics and Therapeutics
Clinicum
Date: 2016-06
Language: eng
Number of pages: 10
Belongs to series: Clinical Neuroradiology
ISSN: 1869-1439
DOI: https://doi.org/10.1007/s00062-014-0349-8
URI: http://hdl.handle.net/10138/224104
Abstract: Reproducibility of two different methods for quantifying fiber tracts by using a diffusion tensor imaging (DTI) sequence suitable for clinical magnetic resonance imaging (MRI) protocols was evaluated. DTI of 15 subjects was used to analyze intra-rater and inter-rater reproducibility. Another 10 subjects underwent MRI twice for assessment of between-scan reliability. Ten long association tracts were defined by fiber tracking using inclusion and exclusion regions of interest (ROIs). Whole-tract analysis and tractography-based core analysis were performed, and the effect of fractional anisotropy (FA 0.15/0.30) and turning angle threshold (27A degrees/60A degrees) on reproducibility was evaluated. Additionally, ROI measurements were performed in the core of the tracts. For the tract-based methods, intra-rater and inter-rater reliabilities of FA and mean diffusivity (MD) measurements were excellent. Between-scan reproducibility was good or excellent in 127 of 130 of the measurements. There was no systematic difference in the reproducibility of the FA, MD, and volume measurements depending on the FA or turning angle threshold. For the cross-sectional ROI measurements, reliability showed large variation from poor to excellent depending on the tract. Compared with the commonly used cross-sectional core ROI method, the tract-based analyses seem to be a more robust way to identify and measure white matter tracts of interest, and provide a novel reproducible tool to perform core analysis.
Subject: Reproducibility
DTI tractography
Core ROI method
Tract-based analyses
DIFFUSION-TENSOR TRACTOGRAPHY
TRAUMATIC BRAIN-INJURY
AMYOTROPHIC-LATERAL-SCLEROSIS
CEREBRAL WHITE-MATTER
UNCINATE FASCICULUS
RELIABILITY
MR
ABNORMALITIES
DISTORTION
INTEGRITY
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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