Reproducibility of Tract-based and Region-of-Interest DTI Analysis of Long Association Tracts

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dc.contributor.author Brandstack, Nina
dc.contributor.author Kurki, T.
dc.contributor.author Laalo, J.
dc.contributor.author Kauko, T.
dc.contributor.author Tenovuo, O.
dc.date.accessioned 2017-09-14T09:56:31Z
dc.date.available 2021-12-16T22:45:20Z
dc.date.issued 2016-06
dc.identifier.citation Brandstack , N , Kurki , T , Laalo , J , Kauko , T & Tenovuo , O 2016 , ' Reproducibility of Tract-based and Region-of-Interest DTI Analysis of Long Association Tracts ' , Clinical Neuroradiology , vol. 26 , no. 2 , pp. 199-208 . https://doi.org/10.1007/s00062-014-0349-8
dc.identifier.other PURE: 66853111
dc.identifier.other PURE UUID: a8b37494-1599-4714-b9c5-602964ec1359
dc.identifier.other WOS: 000379009000010
dc.identifier.other Scopus: 84907684899
dc.identifier.uri http://hdl.handle.net/10138/224104
dc.description.abstract Reproducibility of two different methods for quantifying fiber tracts by using a diffusion tensor imaging (DTI) sequence suitable for clinical magnetic resonance imaging (MRI) protocols was evaluated. DTI of 15 subjects was used to analyze intra-rater and inter-rater reproducibility. Another 10 subjects underwent MRI twice for assessment of between-scan reliability. Ten long association tracts were defined by fiber tracking using inclusion and exclusion regions of interest (ROIs). Whole-tract analysis and tractography-based core analysis were performed, and the effect of fractional anisotropy (FA 0.15/0.30) and turning angle threshold (27A degrees/60A degrees) on reproducibility was evaluated. Additionally, ROI measurements were performed in the core of the tracts. For the tract-based methods, intra-rater and inter-rater reliabilities of FA and mean diffusivity (MD) measurements were excellent. Between-scan reproducibility was good or excellent in 127 of 130 of the measurements. There was no systematic difference in the reproducibility of the FA, MD, and volume measurements depending on the FA or turning angle threshold. For the cross-sectional ROI measurements, reliability showed large variation from poor to excellent depending on the tract. Compared with the commonly used cross-sectional core ROI method, the tract-based analyses seem to be a more robust way to identify and measure white matter tracts of interest, and provide a novel reproducible tool to perform core analysis. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Clinical Neuroradiology
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Reproducibility
dc.subject DTI tractography
dc.subject Core ROI method
dc.subject Tract-based analyses
dc.subject DIFFUSION-TENSOR TRACTOGRAPHY
dc.subject TRAUMATIC BRAIN-INJURY
dc.subject AMYOTROPHIC-LATERAL-SCLEROSIS
dc.subject CEREBRAL WHITE-MATTER
dc.subject UNCINATE FASCICULUS
dc.subject RELIABILITY
dc.subject MR
dc.subject ABNORMALITIES
dc.subject DISTORTION
dc.subject INTEGRITY
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.title Reproducibility of Tract-based and Region-of-Interest DTI Analysis of Long Association Tracts en
dc.type Article
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization Clinicum
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1007/s00062-014-0349-8
dc.relation.issn 1869-1439
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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