Current concepts in chronic inflammatory diseases : Interactions between microbes, cellular metabolism, and inflammation

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Garn , H , Bahn , S , Baune , B T , Binder , E B , Bisgaard , H , Chatila , T A , Chavakis , T , Culmsee , C , Dannlowski , U , Gay , S , Gern , J , Haahtela , T , Kircher , T , Mueller-Ladner , U , Neurath , M F , Preissner , K T , Reinhardt , C , Rook , G , Russell , S , Schmeck , B , Stappenbeck , T , Steinhoff , U , van Os , J , Weiss , S , Zemlin , M & Renz , H 2016 , ' Current concepts in chronic inflammatory diseases : Interactions between microbes, cellular metabolism, and inflammation ' , Journal of Allergy and Clinical Immunology , vol. 138 , no. 1 , pp. 47-56 . https://doi.org/10.1016/j.jaci.2016.02.046

Title: Current concepts in chronic inflammatory diseases : Interactions between microbes, cellular metabolism, and inflammation
Author: Garn, Holger; Bahn, Sabine; Baune, Bernhard T.; Binder, Elisabeth B.; Bisgaard, Hans; Chatila, Talal A.; Chavakis, Triantafyllos; Culmsee, Carsten; Dannlowski, Udo; Gay, Steffen; Gern, James; Haahtela, Tari; Kircher, Tilo; Mueller-Ladner, Ulf; Neurath, Markus F.; Preissner, Klaus T.; Reinhardt, Christoph; Rook, Graham; Russell, Shannon; Schmeck, Bernd; Stappenbeck, Thaddeus; Steinhoff, Ulrich; van Os, Jim; Weiss, Scott; Zemlin, Michael; Renz, Harald
Contributor organization: Clinicum
Department of Dermatology, Allergology and Venereology
Date: 2016-07
Language: eng
Number of pages: 10
Belongs to series: Journal of Allergy and Clinical Immunology
ISSN: 0091-6749
DOI: https://doi.org/10.1016/j.jaci.2016.02.046
URI: http://hdl.handle.net/10138/224107
Abstract: Recent research indicates that chronic inflammatory diseases, including allergies and autoimmune and neuropsychiatric diseases, share common pathways of cellular and molecular dysregulation. It was the aim of the International von-Behring-Rontgen Symposium (October 16-18, 2014, in Marburg, Germany) to discuss recent developments in this field. These include a concept of biodiversity; the contribution of urbanization, lifestyle factors, and nutrition (eg, vitamin D); and new mechanisms of metabolic and immune dysregulation, such as extracellular and intracellular RNAs and cellular and mitochondrial stress. Epigenetic mechanisms contribute further to altered gene expression and therefore to the development of chronic inflammation. These novel findings provide the foundation for further development of preventive and therapeutic strategies.
Subject: Chronic inflammation
immune dysregulation
metabolism
environment
epigenetics
stress
biodiversity
EARLY-LIFE
VITAMIN-D
RHEUMATOID-ARTHRITIS
EXTRACELLULAR RNA
SCHIZOPHRENIA-PATIENTS
INTESTINAL MICROBIOTA
IMMUNE-RESPONSES
CHILDHOOD ASTHMA
GUT MICROBIOTA
ANTIBIOTIC USE
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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