Long-term risk of renal and urinary tract diseases in childhood cancer survivors : A population-based cohort study

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dc.contributor.author Bonnesen, Trine Gade
dc.contributor.author Winther, Jeanette F.
dc.contributor.author Asdahl, Peter H.
dc.contributor.author Licht, Sofie de Fine
dc.contributor.author Gudmundsdottir, Thorgerdur
dc.contributor.author Holmqvist, Anna Saellfors
dc.contributor.author Madanat-Harjuoja, Laura-Maria
dc.contributor.author Tryggvadottir, Laufey
dc.contributor.author Wesenberg, Finn
dc.contributor.author Birn, Henrik
dc.contributor.author Olsen, Jorgen H.
dc.contributor.author Hasle, Henrik
dc.contributor.author ALiCCS Study Grp
dc.date.accessioned 2017-09-14T09:56:52Z
dc.date.available 2021-12-17T18:49:31Z
dc.date.issued 2016-09
dc.identifier.citation Bonnesen , T G , Winther , J F , Asdahl , P H , Licht , S D F , Gudmundsdottir , T , Holmqvist , A S , Madanat-Harjuoja , L-M , Tryggvadottir , L , Wesenberg , F , Birn , H , Olsen , J H , Hasle , H & ALiCCS Study Grp 2016 , ' Long-term risk of renal and urinary tract diseases in childhood cancer survivors : A population-based cohort study ' , European Journal of Cancer , vol. 64 , pp. 52-61 . https://doi.org/10.1016/j.ejca.2016.05.006
dc.identifier.other PURE: 68192766
dc.identifier.other PURE UUID: a75d1df3-ba11-410e-9f83-cf278bd54b35
dc.identifier.other WOS: 000380750800006
dc.identifier.other Scopus: 84975131390
dc.identifier.uri http://hdl.handle.net/10138/224120
dc.description.abstract Background: Childhood cancer has been associated with long-term risk of urinary tract diseases, but risk patterns remain to be comprehensively investigated. We analysed the lifetime risk of urinary tract diseases in survivors of childhood cancer in the Nordic countries. Methods: We identified 32,519 one-year survivors of childhood cancer diagnosed since the 1940s and 1950s in the five Nordic cancer registries and selected 211,156 population comparisons of a corresponding age, sex, and country of residence from the national population registries. To obtain information on all first-time hospitalizations for a urinary tract disease, we linked all study subjects to the national hospital registry of each country. Relative risks (RRs) and absolute excess risks (AERs) and associated 95% confidence intervals (CIs) for urinary tract diseases among cancer survivors were calculated with the appropriate morbidity rates among comparisons as reference. Results: We observed 1645 childhood cancer survivors ever hospitalized for urinary tract disease yielding an RR of 2.5 (95% CI 2.4-2.7) and an AER of 229 (95% CI 210-248) per 100,000 person-years. The cumulative risk at age 60 was 22% in cancer survivors and 10% in comparisons. Infections of the urinary system and chronic kidney disease showed the highest excess risks, whereas survivors of neuroblastoma, hepatic and renal tumours experienced the highest RRs. Conclusion: Survivors of childhood cancer had an excess risk of urinary tract diseases and for most diseases the risk remained elevated throughout life. The highest risks occurred following therapy of childhood abdominal tumours. (C) 2016 Elsevier Ltd. All rights reserved. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof European Journal of Cancer
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Childhood cancer
dc.subject Survivorship
dc.subject Late complications
dc.subject Renal diseases
dc.subject Urinary tract diseases
dc.subject IFOSFAMIDE-INDUCED NEPHROTOXICITY
dc.subject CONGESTIVE-HEART-FAILURE
dc.subject ADULT SURVIVORS
dc.subject DATA QUALITY
dc.subject PEDIATRIC-PATIENTS
dc.subject FOLLOW-UP
dc.subject REGISTER
dc.subject COMPLETENESS
dc.subject CHILDREN
dc.subject COMPARABILITY
dc.subject 3122 Cancers
dc.title Long-term risk of renal and urinary tract diseases in childhood cancer survivors : A population-based cohort study en
dc.type Article
dc.contributor.organization Children's Hospital
dc.contributor.organization Lastentautien yksikkö
dc.contributor.organization Clinicum
dc.contributor.organization HUS Children and Adolescents
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.ejca.2016.05.006
dc.relation.issn 0959-8049
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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