A single dose of mirtazapine attenuates neural responses to self-referential processing

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http://hdl.handle.net/10138/224142

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Komulainen , E , Heikkila , R , Meskanen , K , Raij , T T , Nummenmaa , L , Lahti , J , Jylhä , P , Melartin , T , Harmer , C J , Isometsa , E & Ekelund , J 2016 , ' A single dose of mirtazapine attenuates neural responses to self-referential processing ' Journal of Psychopharmacology , vol 30 , no. 1 , pp. 23-32 . DOI: 10.1177/0269881115616384

Titel: A single dose of mirtazapine attenuates neural responses to self-referential processing
Författare: Komulainen, Emma; Heikkila, Roope; Meskanen, Katarina; Raij, Tuukka T.; Nummenmaa, Lauri; Lahti, Jari; Jylhä, Pekka; Melartin, Tarja; Harmer, Catherine J.; Isometsa, Erkki; Ekelund, Jesper
Medarbetare: University of Helsinki, Clinicum
University of Helsinki, Institute of Behavioural Sciences
University of Helsinki, Psykiatrian osasto
University of Helsinki, Clinicum
University of Helsinki, Institute of Behavioural Sciences
University of Helsinki, Psykiatrian osasto
University of Helsinki, Psykiatrian osasto
University of Helsinki, Clinicum
University of Helsinki, Clinicum


Utgivare: SAGE SCIENCE PRESS (UK)
Datum: 2016-01
Språk: eng
Sidantal: 10
Tillhör serie: Journal of Psychopharmacology
ISSN: 0269-8811
DOI: http://dx.doi.org/10.1177/0269881115616384
Permanenta länken (URI): http://hdl.handle.net/10138/224142
Abstrakt: Increased self-focus is a core factor in the psychopathology of depression. Cortical midline structures (CMS) are implicated in the neurobiology of self, depression and antidepressant treatment response. Mirtazapine, an antidepressant that increases serotonin and norepinephrine release, enhances processing of positive and attenuates processing of negative emotional information in healthy volunteers after a single dose. These early changes, which are opposite to the negative information bias in depression, may be important for the therapeutic effect of mirtazapine. It nevertheless remains unresolved whether/how mirtazapine specifically influences processing of self-referential emotional information. Half of the healthy volunteers (n=15/30) received a single dose of mirtazapine, in an open-label design, two hours before functional magnetic resonance imaging (fMRI), and the other half was scanned as a control group without medication. During fMRI the participants categorized positive and negative self-referential adjectives. Mirtazapine attenuated responses to self-referential processing in the medial prefrontal cortex and the anterior cingulate cortex. Mirtazapine further decreased responses to positive self-referential processing in the posterior cingulate cortex and parietal cortex. These decreased responses of the CMS suggest that mirtazapine may rapidly improve the ability of the CMS to down-regulate self-referential processing. In depressed patients, this could lead to decreased self-focus and rumination, contributing to the antidepressant effect.
Subject: Antidepressant
mirtazapine
fMRI
emotions
self-referential processing
MAJOR DEPRESSIVE DISORDER
MEDIAL PREFRONTAL CORTEX
FUNCTIONAL MAGNETIC-RESONANCE
DEFAULT-MODE NETWORK
HEALTHY-VOLUNTEERS
NEURONAL RESPONSES
SELECTIVE SEROTONIN
AMYGDALA REACTIVITY
EMOTIONAL FACES
ANXIETY
515 Psychology
3124 Neurology and psychiatry
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