A single dose of mirtazapine attenuates neural responses to self-referential processing

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dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Institute of Behavioural Sciences en
dc.contributor University of Helsinki, Psykiatrian osasto en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Institute of Behavioural Sciences en
dc.contributor University of Helsinki, Psykiatrian osasto en
dc.contributor University of Helsinki, Psykiatrian osasto en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Clinicum en
dc.contributor.author Komulainen, Emma
dc.contributor.author Heikkila, Roope
dc.contributor.author Meskanen, Katarina
dc.contributor.author Raij, Tuukka T.
dc.contributor.author Nummenmaa, Lauri
dc.contributor.author Lahti, Jari
dc.contributor.author Jylhä, Pekka
dc.contributor.author Melartin, Tarja
dc.contributor.author Harmer, Catherine J.
dc.contributor.author Isometsa, Erkki
dc.contributor.author Ekelund, Jesper
dc.date.accessioned 2017-09-14T09:57:22Z
dc.date.available 2017-09-14T09:57:22Z
dc.date.issued 2016-01
dc.identifier.citation Komulainen , E , Heikkila , R , Meskanen , K , Raij , T T , Nummenmaa , L , Lahti , J , Jylhä , P , Melartin , T , Harmer , C J , Isometsa , E & Ekelund , J 2016 , ' A single dose of mirtazapine attenuates neural responses to self-referential processing ' Journal of Psychopharmacology , vol 30 , no. 1 , pp. 23-32 . DOI: 10.1177/0269881115616384 en
dc.identifier.issn 0269-8811
dc.identifier.other PURE: 58999471
dc.identifier.other PURE UUID: 8282cf6a-39d0-4db1-8929-a758c560c1b0
dc.identifier.other WOS: 000367382300003
dc.identifier.other Scopus: 84951987880
dc.identifier.uri http://hdl.handle.net/10138/224142
dc.description.abstract Increased self-focus is a core factor in the psychopathology of depression. Cortical midline structures (CMS) are implicated in the neurobiology of self, depression and antidepressant treatment response. Mirtazapine, an antidepressant that increases serotonin and norepinephrine release, enhances processing of positive and attenuates processing of negative emotional information in healthy volunteers after a single dose. These early changes, which are opposite to the negative information bias in depression, may be important for the therapeutic effect of mirtazapine. It nevertheless remains unresolved whether/how mirtazapine specifically influences processing of self-referential emotional information. Half of the healthy volunteers (n=15/30) received a single dose of mirtazapine, in an open-label design, two hours before functional magnetic resonance imaging (fMRI), and the other half was scanned as a control group without medication. During fMRI the participants categorized positive and negative self-referential adjectives. Mirtazapine attenuated responses to self-referential processing in the medial prefrontal cortex and the anterior cingulate cortex. Mirtazapine further decreased responses to positive self-referential processing in the posterior cingulate cortex and parietal cortex. These decreased responses of the CMS suggest that mirtazapine may rapidly improve the ability of the CMS to down-regulate self-referential processing. In depressed patients, this could lead to decreased self-focus and rumination, contributing to the antidepressant effect. en
dc.format.extent 10
dc.language.iso eng
dc.publisher SAGE SCIENCE PRESS (UK)
dc.relation.ispartof Journal of Psychopharmacology
dc.rights en
dc.subject Antidepressant en
dc.subject mirtazapine en
dc.subject fMRI en
dc.subject emotions en
dc.subject self-referential processing en
dc.subject MAJOR DEPRESSIVE DISORDER en
dc.subject MEDIAL PREFRONTAL CORTEX en
dc.subject FUNCTIONAL MAGNETIC-RESONANCE en
dc.subject DEFAULT-MODE NETWORK en
dc.subject HEALTHY-VOLUNTEERS en
dc.subject NEURONAL RESPONSES en
dc.subject SELECTIVE SEROTONIN en
dc.subject AMYGDALA REACTIVITY en
dc.subject EMOTIONAL FACES en
dc.subject ANXIETY en
dc.subject 515 Psychology en
dc.subject 3124 Neurology and psychiatry en
dc.title A single dose of mirtazapine attenuates neural responses to self-referential processing en
dc.type A1 Refereed journal article
dc.description.version Peer reviewed
dc.identifier.doi http://dx.doi.org/10.1177/0269881115616384
dc.type.uri info:eu-repo/semantics/article
dc.type.uri info:eu-repo/semantics/publishedVersion
dc.contributor.pbl
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