Analysis of infant cortical synchrony is constrained by the number of recording electrodes and the recording montage

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Tokariev , A , Vanhatalo , S & Palva , J M 2016 , ' Analysis of infant cortical synchrony is constrained by the number of recording electrodes and the recording montage ' Clinical Neurophysiology , vol 127 , no. 1 , pp. 310-323 . DOI: 10.1016/j.clinph.2015.04.291

Title: Analysis of infant cortical synchrony is constrained by the number of recording electrodes and the recording montage
Author: Tokariev, Anton; Vanhatalo, Sampsa; Palva, J. Matias
Other contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Neuroscience Center




Publisher: ELSEVIER IRELAND LTD
Date: 2016-01
Language: eng
Number of pages: 14
Belongs to series: Clinical Neurophysiology
ISSN: 1388-2457
DOI: http://dx.doi.org/10.1016/j.clinph.2015.04.291
URI: http://hdl.handle.net/10138/224150
Abstract: Objective: To assess how the recording montage in the neonatal EEG influences the detection of cortical source signals and their phase interactions. Methods: Scalp EEG was simulated by forward modeling 20-200 simultaneously active sources covering the cortical surface of a realistic neonatal head model. We assessed systematically how the number of scalp electrodes (11-85), analysis montage, or the size of cortical sources affect the detection of cortical phase synchrony. Statistical metrics were developed for quantifying the resolution and reliability of the montages. Results: The findings converge to show that an increase in the number of recording electrodes leads to a systematic improvement in the detection of true cortical phase synchrony. While there is always a ceiling effect with respect to discernible cortical details, we show that the average and Laplacian montages exhibit superior specificity and sensitivity as compared to other conventional montages. Conclusions: Reliability in assessing true neonatal cortical synchrony is directly related to the choice of EEG recording and analysis configurations. Because of the high conductivity of the neonatal skull, the conventional neonatal EEG recordings are spatially far too sparse for pertinent studies, and this loss of information cannot be recovered by re-montaging during analysis. Significance: Future neonatal EEG studies will need prospective planning of recording configuration to allow analysis of spatial details required by each study question. Our findings also advice about the level of details in brain synchrony that can be studied with existing datasets or by using conventional EEG recordings. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Subject: Neonatal EEG
Forward model
Simulation
Dense array EEG
Connectivity
Brain development
PRINCIPAL-COMPONENTS-ANALYSIS
AUDITORY EVOKED-POTENTIALS
ERP GENERATOR PATTERNS
LAPLACIAN WAVE-FORMS
SOURCE LOCALIZATION
BRAIN NETWORKS
NEONATAL EEG
ADULT ELECTROENCEPHALOGRAM
FUNCTIONAL CONNECTIVITY
SPATIAL-RESOLUTION
3124 Neurology and psychiatry
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