Analysis of infant cortical synchrony is constrained by the number of recording electrodes and the recording montage

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dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Neuroscience Center en
dc.contributor.author Tokariev, Anton
dc.contributor.author Vanhatalo, Sampsa
dc.contributor.author Palva, J. Matias
dc.date.accessioned 2017-09-14T09:57:31Z
dc.date.available 2017-09-14T09:57:31Z
dc.date.issued 2016-01
dc.identifier.citation Tokariev , A , Vanhatalo , S & Palva , J M 2016 , ' Analysis of infant cortical synchrony is constrained by the number of recording electrodes and the recording montage ' Clinical Neurophysiology , vol 127 , no. 1 , pp. 310-323 . DOI: 10.1016/j.clinph.2015.04.291 en
dc.identifier.issn 1388-2457
dc.identifier.other PURE: 59635599
dc.identifier.other PURE UUID: e78aa876-7fd5-4ebb-ad68-0091ce37b7ca
dc.identifier.other WOS: 000367540800043
dc.identifier.other Scopus: 84932121669
dc.identifier.uri http://hdl.handle.net/10138/224150
dc.description.abstract Objective: To assess how the recording montage in the neonatal EEG influences the detection of cortical source signals and their phase interactions. Methods: Scalp EEG was simulated by forward modeling 20-200 simultaneously active sources covering the cortical surface of a realistic neonatal head model. We assessed systematically how the number of scalp electrodes (11-85), analysis montage, or the size of cortical sources affect the detection of cortical phase synchrony. Statistical metrics were developed for quantifying the resolution and reliability of the montages. Results: The findings converge to show that an increase in the number of recording electrodes leads to a systematic improvement in the detection of true cortical phase synchrony. While there is always a ceiling effect with respect to discernible cortical details, we show that the average and Laplacian montages exhibit superior specificity and sensitivity as compared to other conventional montages. Conclusions: Reliability in assessing true neonatal cortical synchrony is directly related to the choice of EEG recording and analysis configurations. Because of the high conductivity of the neonatal skull, the conventional neonatal EEG recordings are spatially far too sparse for pertinent studies, and this loss of information cannot be recovered by re-montaging during analysis. Significance: Future neonatal EEG studies will need prospective planning of recording configuration to allow analysis of spatial details required by each study question. Our findings also advice about the level of details in brain synchrony that can be studied with existing datasets or by using conventional EEG recordings. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. en
dc.format.extent 14
dc.language.iso eng
dc.publisher ELSEVIER IRELAND LTD
dc.relation.ispartof Clinical Neurophysiology
dc.rights en
dc.subject Neonatal EEG en
dc.subject Forward model en
dc.subject Simulation en
dc.subject Dense array EEG en
dc.subject Connectivity en
dc.subject Brain development en
dc.subject PRINCIPAL-COMPONENTS-ANALYSIS en
dc.subject AUDITORY EVOKED-POTENTIALS en
dc.subject ERP GENERATOR PATTERNS en
dc.subject LAPLACIAN WAVE-FORMS en
dc.subject SOURCE LOCALIZATION en
dc.subject BRAIN NETWORKS en
dc.subject NEONATAL EEG en
dc.subject ADULT ELECTROENCEPHALOGRAM en
dc.subject FUNCTIONAL CONNECTIVITY en
dc.subject SPATIAL-RESOLUTION en
dc.subject 3124 Neurology and psychiatry en
dc.title Analysis of infant cortical synchrony is constrained by the number of recording electrodes and the recording montage en
dc.type A1 Refereed journal article
dc.description.version Peer reviewed
dc.identifier.doi http://dx.doi.org/10.1016/j.clinph.2015.04.291
dc.type.uri info:eu-repo/semantics/article
dc.type.uri info:eu-repo/semantics/publishedVersion
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