Composition of human faecal microbiota in resistance to Campylobacter infection

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dc.contributor.author Kampmann, C.
dc.contributor.author Dicksved, J.
dc.contributor.author Engstrand, L.
dc.contributor.author Rautelin, H.
dc.date.accessioned 2017-09-18T07:56:00Z
dc.date.available 2017-09-18T07:56:00Z
dc.date.issued 2016-01
dc.identifier.citation Kampmann , C , Dicksved , J , Engstrand , L & Rautelin , H 2016 , ' Composition of human faecal microbiota in resistance to Campylobacter infection ' , Clinical Microbiology and Infection , vol. 22 , no. 1 . https://doi.org/10.1016/j.cmi.2015.09.004
dc.identifier.other PURE: 59533791
dc.identifier.other PURE UUID: 19226692-68e2-463e-b6fe-83acf6860b3a
dc.identifier.other WOS: 000368024800016
dc.identifier.other Scopus: 84951855646
dc.identifier.uri http://hdl.handle.net/10138/224241
dc.description.abstract In mice, specific species composition of gut microbiota enhances susceptibility to Campylobacter jejuni but little is known about the specific composition of the human gut microbiota in providing protection from infections caused by enteropathogens. Healthy adult individuals, who travelled in groups from Sweden to destinations with an estimated high risk for acquisition of Campylobacter infection, were enrolled. Faecal samples, collected before travelling and after returning home, were cultured for bacterial enteropathogens, and analysed for Campylobacter by PCR and for the species composition of the microbiota by 16S amplicon massive parallel sequencing. The microbiota compositions were compared between persons who became infected during their travel and those who did not. A total of 63 participants completed the study; 14 became infected with Campylobacter, two with Salmonella and 47 remained negative for the enteropathogens tested. After exclusion of samples taken after antimicrobial treatment, 49 individuals were included in the final analyses. Intra-individual stability of the microbiota was demonstrated for samples taken before travelling. The original diversity of the faecal microbiota was significantly lower among individuals who later became infected compared with those who remained uninfected. The relative abundances of bacteria belonging to the family Lachnospiraceae, and more specifically its two genera Dorea and Coprococcus, were significantly higher among those who remained uninfected. The travel-related infection did not significantly modify the faecal microbiota composition. Species composition of human gut microbiota is important for colonization resistance to Campylobacter infection. Especially individuals with a lower diversity are more susceptible to Campylobacter infection. (C) 2015 The Authors. Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Clinical Microbiology and Infection
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Campylobacter
dc.subject colonization resistance
dc.subject enteritis
dc.subject infection
dc.subject microbiota
dc.subject GUT MICROBIOTA
dc.subject CLOSTRIDIUM-DIFFICILE
dc.subject PCR
dc.subject IDENTIFICATION
dc.subject JEJUNI
dc.subject COLI
dc.subject 3111 Biomedicine
dc.title Composition of human faecal microbiota in resistance to Campylobacter infection en
dc.type Article
dc.contributor.organization Medicum
dc.contributor.organization Department of Bacteriology and Immunology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.cmi.2015.09.004
dc.relation.issn 1198-743X
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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