Assessing the contributions of childhood maltreatment subtypes and depression case-control status on telomere length reveals a specific role of physical neglect

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dc.contributor.author Vincent, John
dc.contributor.author Hovatta, Iiris
dc.contributor.author Frissa, Souci
dc.contributor.author Goodwin, Laura
dc.contributor.author Hotopf, Matthew
dc.contributor.author Hatch, Stephani L.
dc.contributor.author Breen, Gerome
dc.contributor.author Powell, Timothy R.
dc.date.accessioned 2017-09-18T10:22:00Z
dc.date.available 2017-09-18T10:22:00Z
dc.date.issued 2017-04-15
dc.identifier.citation Vincent , J , Hovatta , I , Frissa , S , Goodwin , L , Hotopf , M , Hatch , S L , Breen , G & Powell , T R 2017 , ' Assessing the contributions of childhood maltreatment subtypes and depression case-control status on telomere length reveals a specific role of physical neglect ' , Journal of Affective Disorders , vol. 213 , pp. 16-22 . https://doi.org/10.1016/j.jad.2017.01.031
dc.identifier.other PURE: 84107570
dc.identifier.other PURE UUID: a389b513-5d0a-4cb3-aa51-6febee8274ba
dc.identifier.other WOS: 000398868300003
dc.identifier.other Scopus: 85011850864
dc.identifier.other ORCID: /0000-0002-5990-7892/work/32700635
dc.identifier.uri http://hdl.handle.net/10138/224261
dc.description.abstract Background: Studies have provided evidence that both childhood maltreatment and depressive disorders are associated with shortened telomere lengths. However, as childhood maltreatment is a risk factor for depression, it remains unclear whether this may be driving shortened telomere lengths observed amongst depressed patients. Furthermore, it's unclear if the effects of maltreatment on telomere length shortening are more pervasive amongst depressed patients relative to controls, and consequently whether biological ageing may contribute to depression's pathophysiology. The current study assesses the effects of childhood maltreatment, depression case/control status, and the interactive effect of both childhood maltreatment and depression case/control status on relative telomere length (RTL). Method: DNA samples from 80 depressed subjects and 100 control subjects were utilized from a U.K. sample (ages 20-84), with childhood trauma questionnaire data available for all participants. RTL was quantified using quantitative polymerase chain reactions. Univariate linear regression analyses were used to assess the effects of depression status, childhood maltreatment and depression by childhood maltreatment interactions on RTL. The false discovery rate (q <0.05) was used for multiple testing correction. Results: Analysis of depression case/control status showed no significant main effect on RTL. Four subtypes of childhood maltreatment also demonstrated no significant main effect on RTL, however a history of physical neglect did significantly predict shorter RTL in adulthood (F(1, 174)=7.559, p=0.007, q=0.042, Variance Explained=4.2%), which was independent of case/control status. RTL was further predicted by severity of physical neglect, with the greatest differences observed in older maltreated individuals ( > 50 years old). There were no significant depression case/control status by childhood maltreatment interactions. Limitations: A relatively small sample limited our power to detect interaction effects, and we were unable to consider depression chronicity or recurrence. Conclusion: Shortened RTL was specifically associated with childhood physical neglect, but not the other subtypes of maltreatment or depression case/control status. Our results suggest that the telomere-eroding effects of physical neglect may represent a biological mechanism important in increasing risk for ageing-related disorders. As physical neglect is more frequent amongst depressed cases generally, it may also represent a confounding factor driving previous associations between shorter RTL and depression case status. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Journal of Affective Disorders
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject PSYCHIATRIC-DISORDERS
dc.subject LONDON COMMUNITY
dc.subject MENTAL-ILLNESS
dc.subject MOOD DISORDERS
dc.subject HEALTH
dc.subject DISEASE
dc.subject ANXIETY
dc.subject 3124 Neurology and psychiatry
dc.title Assessing the contributions of childhood maltreatment subtypes and depression case-control status on telomere length reveals a specific role of physical neglect en
dc.type Article
dc.contributor.organization Biosciences
dc.contributor.organization Iiris Hovatta / Principal Investigator
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.jad.2017.01.031
dc.relation.issn 0165-0327
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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