Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders

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http://hdl.handle.net/10138/224336

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Nadjar , A , Wigren , H-K M & Tremblay , M-E 2017 , ' Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders ' , Frontiers in Cellular Neuroscience , vol. 11 , 250 . https://doi.org/10.3389/fncel.2017.00250

Title: Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders
Author: Nadjar, Agnes; Wigren, Henna-Kaisa M.; Tremblay, Marie-Eve
Contributor: University of Helsinki, Medicum
Date: 2017-08-30
Language: eng
Number of pages: 11
Belongs to series: Frontiers in Cellular Neuroscience
ISSN: 1662-5102
URI: http://hdl.handle.net/10138/224336
Abstract: Sleep serves crucial learning and memory functions in both nervous and immune systems. Microglia are brain immune cells that actively maintain health through their crucial physiological roles exerted across the lifespan, including phagocytosis of cellular debris and orchestration of neuroinflammation. The past decade has witnessed an explosive growth of microglial research. Considering the recent developments in the field of microglia and sleep, we examine their possible impact on various pathological conditions associated with a gain, disruption, or loss of sleep in this focused mini-review. While there are extensive studies of microglial implication in a variety of neuropsychiatric and neurodegenerative diseases, less is known regarding their roles in sleep disorders. It is timely to stimulate new research in this emergent and rapidly growing field of investigation.
Subject: microglia
sleep
wakefulness
disease models
animal
diseases
TUMOR-NECROSIS-FACTOR
CHRONIC INTERMITTENT HYPOXIA
CENTRAL-NERVOUS-SYSTEM
ADIPOSE-TISSUE INFLAMMATION
LESS-THAN-1 HZ OSCILLATION
EYE-MOVEMENT SLEEP
FACTOR-ALPHA
IN-VIVO
TNF-ALPHA
INSULIN-RESISTANCE
3112 Neurosciences
3124 Neurology and psychiatry
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