Antidepressant use and work-related injuries

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http://hdl.handle.net/10138/224372

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Kouvonen , A , Vahtera , J , Pentti , J , Korhonen , M J , Oksanen , T , Salo , P , Virtanen , M & Kivimaki , M 2016 , ' Antidepressant use and work-related injuries ' , Psychological Medicine , vol. 46 , no. 7 , pp. 1391-1399 . https://doi.org/10.1017/S0033291715002925

Title: Antidepressant use and work-related injuries
Author: Kouvonen, A.; Vahtera, J.; Pentti, J.; Korhonen, M. J.; Oksanen, T.; Salo, P.; Virtanen, M.; Kivimaki, M.
Contributor: University of Helsinki, Department of Social Research (2010-2017)
University of Helsinki, Finnish Institute of Occupational Health (TTL)
University of Helsinki, Clinicum
Date: 2016-05
Language: eng
Number of pages: 9
Belongs to series: Psychological Medicine
ISSN: 0033-2917
URI: http://hdl.handle.net/10138/224372
Abstract: Background. Adverse effects of antidepressants are most common at the beginning of the treatment, but possible also later. We examined the association between antidepressant use and work-related injuries taking into account the duration of antidepressant use. Method. Antidepressant use and work-related injuries between 2000 and 2011 were measured among 66 238 employees (mean age 43.8 years, 80% female) using linkage to national records (the Finnish Public Sector study). We analysed data using time-dependent modelling with individuals as their own controls (self-controlled case-series design). Results. In 2238 individuals who had used antidepressants and had a work-related injury during a mean follow-up of 7.8 years, no increase in the risk of injury was observed in the beginning of antidepressant treatment. However, an increased injury risk was seen after 3 months of treatment (rate ratio, compared with no recent antidepressant use, 1.27, 95% confidence interval 1.10-1.48). This was also the case among those who had used only selective serotonin re-uptake inhibitors (n = 714; rate ratio 1.41, 95% confidence interval 1.08-1.83). Conclusions. Antidepressant use was not associated with an increased risk of work-related injury at the beginning of treatment. Post-hoc analyses of antidepressant trials are needed to determine whether long-term use of antidepressants increases the risk of work-related injury.
Subject: Antidepressants
commuting injuries
occupational injuries
public sector
workplace
work-related injuries
MEDICATION USE
OCCUPATIONAL INJURIES
PROSPECTIVE COHORT
WORKPLACE INJURY
OLDER-PEOPLE
RISK
HEALTH
DEPRESSION
FRACTURES
MORTALITY
3142 Public health care science, environmental and occupational health
515 Psychology
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