Antidepressant use and work-related injuries
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Kouvonen , A , Vahtera , J , Pentti , J , Korhonen , M J , Oksanen , T , Salo , P , Virtanen , M & Kivimaki , M 2016 , ' Antidepressant use and work-related injuries ' , Psychological Medicine , vol. 46 , no. 7 , pp. 1391-1399 . https://doi.org/10.1017/S0033291715002925
| Title: | Antidepressant use and work-related injuries |
| Author: | Kouvonen, A.; Vahtera, J.; Pentti, J.; Korhonen, M. J.; Oksanen, T.; Salo, P.; Virtanen, M.; Kivimaki, M. |
| Contributor: | University of Helsinki, Department of Social Research (2010-2017) University of Helsinki, Finnish Institute of Occupational Health (TTL) University of Helsinki, Clinicum |
| Date: | 2016-05 |
| Language: | eng |
| Number of pages: | 9 |
| Belongs to series: | Psychological Medicine |
| ISSN: | 0033-2917 |
| URI: | http://hdl.handle.net/10138/224372 |
| Abstract: | Background. Adverse effects of antidepressants are most common at the beginning of the treatment, but possible also later. We examined the association between antidepressant use and work-related injuries taking into account the duration of antidepressant use. Method. Antidepressant use and work-related injuries between 2000 and 2011 were measured among 66 238 employees (mean age 43.8 years, 80% female) using linkage to national records (the Finnish Public Sector study). We analysed data using time-dependent modelling with individuals as their own controls (self-controlled case-series design). Results. In 2238 individuals who had used antidepressants and had a work-related injury during a mean follow-up of 7.8 years, no increase in the risk of injury was observed in the beginning of antidepressant treatment. However, an increased injury risk was seen after 3 months of treatment (rate ratio, compared with no recent antidepressant use, 1.27, 95% confidence interval 1.10-1.48). This was also the case among those who had used only selective serotonin re-uptake inhibitors (n = 714; rate ratio 1.41, 95% confidence interval 1.08-1.83). Conclusions. Antidepressant use was not associated with an increased risk of work-related injury at the beginning of treatment. Post-hoc analyses of antidepressant trials are needed to determine whether long-term use of antidepressants increases the risk of work-related injury. |
| Subject: |
Antidepressants
commuting injuries occupational injuries public sector workplace work-related injuries MEDICATION USE OCCUPATIONAL INJURIES PROSPECTIVE COHORT WORKPLACE INJURY OLDER-PEOPLE RISK HEALTH DEPRESSION FRACTURES MORTALITY 3142 Public health care science, environmental and occupational health 515 Psychology |
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