Genome-wide association study of bronchopulmonary dysplasia : a potential role for variants near the CRP gene

Show full item record



Permalink

http://hdl.handle.net/10138/224376

Citation

Mahlman , M , Karjalainen , M K , Huusko , J M , Andersson , S , Kari , M A , Tammela , O K T , Sankilampi , U , Lehtonen , L , Marttila , R H , Bassler , D , Poets , C F , Lacaze-Masmonteil , T , Danan , C , Delacourt , C , Palotie , A , Muglia , L J , Lavoie , P M , Hadchouel , A , Ramet , M & Hallman , M 2017 , ' Genome-wide association study of bronchopulmonary dysplasia : a potential role for variants near the CRP gene ' , Scientific Reports , vol. 7 , 9271 . https://doi.org/10.1038/s41598-017-08977-w

Title: Genome-wide association study of bronchopulmonary dysplasia : a potential role for variants near the CRP gene
Author: Mahlman, Mari; Karjalainen, Minna K.; Huusko, Johanna M.; Andersson, Sture; Kari, M. Anneli; Tammela, Outi K. T.; Sankilampi, Ulla; Lehtonen, Liisa; Marttila, Riitta H.; Bassler, Dirk; Poets, Christian F.; Lacaze-Masmonteil, Thierry; Danan, Claude; Delacourt, Christophe; Palotie, Aarno; Muglia, Louis J.; Lavoie, Pascal M.; Hadchouel, Alice; Ramet, Mika; Hallman, Mikko
Contributor: University of Helsinki, HUS Children and Adolescents
University of Helsinki, Children's Hospital
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2017-08-24
Language: eng
Number of pages: 10
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/224376
Abstract: Bronchopulmonary dysplasia (BPD), the main consequence of prematurity, has a significant heritability, but little is known about predisposing genes. The aim of this study was to identify gene loci predisposing infants to BPD. The initial genome-wide association study (GWAS) included 174 Finnish preterm infants of gestational age 24-30 weeks. Thereafter, the most promising single-nucleotide polymorphisms (SNPs) associated with BPD were genotyped in both Finnish (n = 555) and non-Finnish (n = 388) replication cohorts. Finally, plasma CRP levels from the first week of life and the risk of BPD were assessed. SNP rs11265269, flanking the CRP gene, showed the strongest signal in GWAS (odds ratio [ OR] 3.2, p = 3.4 x 10(-6)). This association was nominally replicated in Finnish and French African populations. A number of other SNPs in the CRP region, including rs3093059, had nominal associations with BPD. During the first week of life the elevated plasma levels of CRP predicted the risk of BPD (OR 3.4, p = 2.9 x 10(-4)) and the SNP rs3093059 associated nominally with plasma CRP levels. Finally, SNP rs11265269 was identified as a risk factor of BPD (OR 1.8, p = 5.3 x 10(-5)), independently of the robust antenatal risk factors. As such, in BPD, a potential role for variants near CRP gene is proposed.
Subject: C-REACTIVE PROTEIN
CHRONIC LUNG-DISEASE
IDENTIFICATION
POPULATION
EXPRESSION
HEALTH
INJURY
SUSCEPTIBILITY
NEWBORNS
OUTCOMES
3111 Biomedicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s41598_017_08977_w.pdf 1.622Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record