Precocious Puberty or Premature Thelarche : analysis of a large Patient series in a single Tertiary center with special emphasis on 6-to 8-Year-Old girls

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Varimo , T , Huttunen , H , Miettinen , P J , Kariola , L , Hietamaki , J , Tarkkanen , A , Hero , M & Raivio , T 2017 , ' Precocious Puberty or Premature Thelarche : analysis of a large Patient series in a single Tertiary center with special emphasis on 6-to 8-Year-Old girls ' , Frontiers in Endocrinology , vol. 8 , 213 . https://doi.org/10.3389/fendo.2017.00213

Title: Precocious Puberty or Premature Thelarche : analysis of a large Patient series in a single Tertiary center with special emphasis on 6-to 8-Year-Old girls
Author: Varimo, Tero; Huttunen, Heta; Miettinen, Paivi Johanna; Kariola, Laura; Hietamaki, Johanna; Tarkkanen, Annika; Hero, Matti; Raivio, Taneli
Contributor: University of Helsinki, Clinicum
University of Helsinki, Research Programs Unit
University of Helsinki, Medicum
University of Helsinki, Children's Hospital
University of Helsinki, Medicum
Date: 2017-08-23
Language: eng
Number of pages: 7
Belongs to series: Frontiers in Endocrinology
ISSN: 1664-2392
URI: http://hdl.handle.net/10138/224379
Abstract: Introduction: We describe the etiology, MRI findings, and growth patterns in girls who had presented with signs of precocious puberty (PP), i.e., premature breast development or early menarche. Special attention was paid to the diagnostic findings in 6- to 8-year-olds. Materials and methods: We reviewed the medical records of 149 girls (aged 0.710.3 years) who had been evaluated for PP in the Helsinki University Hospital between 2001 and 2014. Results: In 6- to 8-year-old girls, PP was most frequently caused by idiopathic gonadotropin-releasing hormone (GnRH)-dependent PP (60%) and premature thelarche (PT; 39%). The former subgroup grew faster (8.7 +/- 2.0 cm/year, n = 58) than the girls with PT (7.0 +/- 1.1 cm/year, n = 32) (P <0.001), and the best discrimination for GnRH-dependent PP was achieved with a growth velocity cut-off value of 7.0 cm/year (sensitivity 92% and specificity 58%) [area under the curve 0.82, 95% confidence interval (CI) 0.730.91, P <0.001]. Among asymptomatic and previously healthy 6- to 8-year-old girls with GnRH-dependent PP, one (1.7%, 95% CI 0.39.7%) had a pathological brain MRI finding requiring surgical intervention (craniopharyngioma). In girls younger than 3 years, the most frequent cause of breast development was PT, and, in 3- to 6-year-olds, GnRH-dependent PP. Conclusion: In 6- to 8-year-old girls, analysis of growth velocity is helpful in differentiating between PT and GnRH-dependent PP. Although the frequency of clinically relevant intracranial findings in previously healthy, asymptomatic 6- to 8-year-old girls was low, they can present without any signs or symptoms, which favors routine MRI imaging also in this age group.
Subject: precocious puberty
premature thelarche
growth velocity
brain MRI
predictors of puberty
NONAROMATIZABLE ANDROGEN
GROWTH
DIAGNOSIS
MATURATION
CHILDHOOD
CHILDREN
MENARCHE
HEIGHT
AGE
TESTOSTERONE
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
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