Cu-Catalyzed ligand-free synthesis of rosuvastatin based novel indole derivatives as potential anticancer agents

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http://hdl.handle.net/10138/224385

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Kumar , K S , Rajesham , B , Ramulu , M S , Bhaskar , B , Dash , S N , Ashfaq , M A , Nagarapu , R , Khan , A A , Lehtonen , S & Pal , M 2016 , ' Cu-Catalyzed ligand-free synthesis of rosuvastatin based novel indole derivatives as potential anticancer agents ' , RSC Advances , vol. 6 , no. 102 , pp. 100487-100493 . https://doi.org/10.1039/c6ra20148b

Title: Cu-Catalyzed ligand-free synthesis of rosuvastatin based novel indole derivatives as potential anticancer agents
Author: Kumar, K. Shiva; Rajesham, Bandari; Ramulu, Meesa Siddi; Bhaskar, Boyapally; Dash, Surjya Narayan; Ashfaq, Mohd Ashraf; Nagarapu, Raju; Khan, Aleem Ahmed; Lehtonen, Sanna; Pal, Manojit
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
Date: 2016
Language: eng
Number of pages: 7
Belongs to series: RSC Advances
ISSN: 2046-2069
URI: http://hdl.handle.net/10138/224385
Abstract: Rosuvastatin based novel indole derivatives designed as potential anti-cancer agents were synthesized via a newly developed ligand-free, simple, straightforward and inexpensive one-pot method. The methodology involved a Cu-catalyzed coupling-cyclization of a rosuvastatin based alkyne with o-iodoanilides in the presence of CuI and K2CO3 in PEG-400. Three of the synthesized compounds showed promising anti-proliferative activities against cancer cell lines and an increase of p21 mRNA expression and apoptotic effects in zebrafish embryos/larvae.
Subject: 2-ETHYNYLANILINE DERIVATIVES
COUPLING-CYCLIZATION
STATIN USE
CANCER
ZEBRAFISH
1-ALKYNES
CYCLOISOMERIZATION
HYDROAMINATION
IDENTIFICATION
2-HETEROARYL
3111 Biomedicine
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