Oxidation of Tyrosine-Phosphopeptides by Titanium Dioxide Photocatalysis

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Ruokolainen , M , Ollikainen , E , Sikanen , T , Kotiaho , T & Kostiainen , R 2016 , ' Oxidation of Tyrosine-Phosphopeptides by Titanium Dioxide Photocatalysis ' , Journal of the American Chemical Society , vol. 138 , no. 24 , pp. 7452-7455 . https://doi.org/10.1021/jacs.6b02472

Title: Oxidation of Tyrosine-Phosphopeptides by Titanium Dioxide Photocatalysis
Author: Ruokolainen, Miina; Ollikainen, Elisa; Sikanen, Tiina; Kotiaho, Tapio; Kostiainen, Risto
Contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
Date: 2016-06-22
Language: eng
Number of pages: 4
Belongs to series: Journal of the American Chemical Society
ISSN: 0002-7863
URI: http://hdl.handle.net/10138/224450
Abstract: Protein phosphorylation has a key role in cell regulation. Oxidation of proteins, in turn, is related to many diseases and to aging, but the effects of phosphorylation on the oxidation of proteins and peptides have been rarely studied. The aim of this study was to examine the mechanistic effect of phosphorylation on peptide oxidation induced by titanium dioxide photo catalysis. The effect of phosphorylation was compared between nonphosphorylated and tyrosine phosphorylated peptides using electrospray tandem mass spectrometry. We observed that tyrosine was the most preferentially oxidized amino acid, but the oxidation reaction was significantly inhibited by its phosphorylation. The study also shows that titanium dioxide photocatalysis provides a fast and easy method to study oxidation reactions of biomolecules, such as peptides.
Subject: SINGLET MOLECULAR-OXYGEN
TIO2 PHOTOCATALYSIS
MICROCYSTIN-LR
METABOLISM
PEPTIDES
PRODUCTS
PROTEINS
CLEAVAGE
116 Chemical sciences
317 Pharmacy
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