Oxidation of Tyrosine-Phosphopeptides by Titanium Dioxide Photocatalysis

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Ruokolainen , M , Ollikainen , E , Sikanen , T , Kotiaho , T & Kostiainen , R 2016 , ' Oxidation of Tyrosine-Phosphopeptides by Titanium Dioxide Photocatalysis ' , Journal of the American Chemical Society , vol. 138 , no. 24 , pp. 7452-7455 . https://doi.org/10.1021/jacs.6b02472

Title: Oxidation of Tyrosine-Phosphopeptides by Titanium Dioxide Photocatalysis
Author: Ruokolainen, Miina; Ollikainen, Elisa; Sikanen, Tiina; Kotiaho, Tapio; Kostiainen, Risto
Contributor organization: Faculty of Pharmacy
Division of Pharmaceutical Chemistry and Technology
Preclinical Drug Formulation and Analysis group
Tiina Sikanen / Chemical Microsystems Lab
Tapio Kotiaho / Principal Investigator
Laboratory of Analytical Chemistry
Department of Chemistry
Risto Kostiainen / Principal Investigator
Drug Research Program
Date: 2016-06-22
Language: eng
Number of pages: 4
Belongs to series: Journal of the American Chemical Society
ISSN: 0002-7863
DOI: https://doi.org/10.1021/jacs.6b02472
URI: http://hdl.handle.net/10138/224450
Abstract: Protein phosphorylation has a key role in cell regulation. Oxidation of proteins, in turn, is related to many diseases and to aging, but the effects of phosphorylation on the oxidation of proteins and peptides have been rarely studied. The aim of this study was to examine the mechanistic effect of phosphorylation on peptide oxidation induced by titanium dioxide photo catalysis. The effect of phosphorylation was compared between nonphosphorylated and tyrosine phosphorylated peptides using electrospray tandem mass spectrometry. We observed that tyrosine was the most preferentially oxidized amino acid, but the oxidation reaction was significantly inhibited by its phosphorylation. The study also shows that titanium dioxide photocatalysis provides a fast and easy method to study oxidation reactions of biomolecules, such as peptides.
116 Chemical sciences
317 Pharmacy
Peer reviewed: Yes
Rights: other
Usage restriction: openAccess
Self-archived version: publishedVersion

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