Chroman-4-one- and Chromone-Based Sirtuin 2 Inhibitors with Antiproliferative Properties in Cancer Cells

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http://hdl.handle.net/10138/224458

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Seifert , T , Malo , M , Kokkola , T , Engen , K , Friden-Saxin , M , Wallen , E A A , Lahtela-Kakkonen , M , Jarho , E M & Luthman , K 2014 , ' Chroman-4-one- and Chromone-Based Sirtuin 2 Inhibitors with Antiproliferative Properties in Cancer Cells ' , Journal of Medicinal Chemistry , vol. 57 , no. 23 , pp. 9870-9888 . https://doi.org/10.1021/jm500930h

Title: Chroman-4-one- and Chromone-Based Sirtuin 2 Inhibitors with Antiproliferative Properties in Cancer Cells
Author: Seifert, Tina; Malo, Marcus; Kokkola, Tarja; Engen, Karin; Friden-Saxin, Maria; Wallen, Erik A. A.; Lahtela-Kakkonen, Maija; Jarho, Elina M.; Luthman, Kristina
Contributor: University of Helsinki, Faculty of Pharmacy
Date: 2014-12-11
Language: eng
Number of pages: 19
Belongs to series: Journal of Medicinal Chemistry
ISSN: 0022-2623
URI: http://hdl.handle.net/10138/224458
Subject: HISTONE DEACETYLASE SIRT2
SMALL-MOLECULE INHIBITOR
CRYSTAL-STRUCTURE
STRUCTURAL BASIS
HISTONE/PROTEIN DEACETYLASES
ADP-RIBOSYLTRANSFERASE
STACKING INTERACTIONS
HUNTINGTONS-DISEASE
BINDING MODE
MECHANISM
317 Pharmacy
116 Chemical sciences
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