Long-Term Paired Associative Stimulation Enhances Motor Output of the Tetraplegic Hand

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Tolmacheva , A , Savolainen , S , Kirveskari , E , Lioumis , P , Kuusela , L , Brandstack , N , Ylinen , A , Mäkelä , J P & Shulga , A 2017 , ' Long-Term Paired Associative Stimulation Enhances Motor Output of the Tetraplegic Hand ' , Journal of Neurotrauma , vol. 34 , no. 18 , pp. 2668-2674 . https://doi.org/10.1089/neu.2017.4996

Title: Long-Term Paired Associative Stimulation Enhances Motor Output of the Tetraplegic Hand
Author: Tolmacheva, Aleksandra; Savolainen, Sarianna; Kirveskari, Erika; Lioumis, Pantelis; Kuusela, Linda; Brandstack, Nina; Ylinen, Aarne; Mäkelä, Jyrki P.; Shulga, Anastasia
Contributor organization: HUS Medical Imaging Center
BioMag Laboratory
Department of Neurosciences
Kliinisen neurofysiologian yksikkö
Department of Physics
Department of Diagnostics and Therapeutics
University of Helsinki
HUS Neurocenter
Neurologian yksikkö
Date: 2017-09-15
Language: eng
Number of pages: 7
Belongs to series: Journal of Neurotrauma
ISSN: 0897-7151
DOI: https://doi.org/10.1089/neu.2017.4996
URI: http://hdl.handle.net/10138/224599
Abstract: A large proportion of spinal cord injuries (SCI) are incomplete. Even in clinically complete injuries, silent non-functional connections can be present. Therapeutic approaches that can strengthen transmission in weak neural connections to improve motor performance are needed. Our aim was to determine whether long-term delivery of paired associative stimulation (PAS, a combination of transcranial magnetic stimulation [TMS] with peripheral nerve stimulation [PNS]) can enhance motor output in the hands of patients with chronic traumatic tetraplegia, and to compare this technique with long-term PNS. Five patients (4 males; age 38-68, mean 48) with no contraindications to TMS received 4 weeks (16 sessions) of stimulation. PAS was given to one hand and PNS combined with sham TMS to the other hand. Patients were blinded to the treatment. Hands were selected randomly. The patients were evaluated by a physiotherapist blinded to the treatment. The follow-up period was 1 month. Patients were evaluated with Daniels and Worthingham's Muscle Testing (0-5 scale) before the first stimulation session, after the last stimulation session, and 1 month after the last stimulation session. One month after the last stimulation session, the improvement in the PAS-treated hand was 1.02 +/- 0.17 points (p <0.0001, n = 100 muscles from 5 patients). The improvement was significantly higher in PAS-treated than in PNS-treated hands (176 +/- 29%, p = 0.046, n = 5 patients). Longterm PAS might be an effective tool for improving motor performance in incomplete chronic SCI patients. Further studies on PAS in larger patient cohorts, with longer stimulation duration and at earlier stages after the injury, are warranted.
Subject: paired associative stimulation
peripheral electrical stimulation
spinal cord injury
transcranial magnetic stimulation
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion

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