dbHiMo : a web-based epigenomics platform for histone-modifying enzymes

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Choi , J , Kim , K-T , Huh , A , Kwon , S , Hong , C , Asiegbu , F O , Jeon , J & Lee , Y-H 2015 , ' dbHiMo : a web-based epigenomics platform for histone-modifying enzymes ' , Database-The journal of biological databases and curation . https://doi.org/10.1093/database/bav052

Title: dbHiMo : a web-based epigenomics platform for histone-modifying enzymes
Author: Choi, Jaeyoung; Kim, Ki-Tae; Huh, Aram; Kwon, Seomun; Hong, Changyoung; Asiegbu, Fred O.; Jeon, Junhyun; Lee, Yong-Hwan
Other contributor: University of Helsinki, Department of Forest Sciences
University of Helsinki, Department of Forest Sciences



Date: 2015-06-08
Language: eng
Number of pages: 10
Belongs to series: Database-The journal of biological databases and curation
ISSN: 1758-0463
DOI: https://doi.org/10.1093/database/bav052
URI: http://hdl.handle.net/10138/225084
Abstract: Over the past two decades, epigenetics has evolved into a key concept for understanding regulation of gene expression. Among many epigenetic mechanisms, covalent modifications such as acetylation and methylation of lysine residues on core histones emerged as a major mechanism in epigenetic regulation. Here, we present the database for histone-modifying enzymes (dbHiMo; http://hme.riceblast.snu.ac.kr/) aimed at facilitating functional and comparative analysis of histone-modifying enzymes (HMEs). HMEs were identified by applying a search pipeline built upon profile hidden Markov model (HMM) to proteomes. The database incorporates 11 576 HMEs identified from 603 proteomes including 483 fungal, 32 plants and 51 metazoan species. The dbHiMo provides users with web-based personalized data browsing and analysis tools, supporting comparative and evolutionary genomics. With comprehensive data entries and associated web-based tools, our database will be a valuable resource for future epigenetics/epigenomics studies.
Subject: CHROMATIN
GENOME
YEAST
GCN5
SEQUENCE
COMPACTION
PHYLOGENY
CROSSTALK
EVOLUTION
PROTEINS
1181 Ecology, evolutionary biology
1184 Genetics, developmental biology, physiology
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