Differences in Homing Potentials of Streptococcus pneumoniae-Specific Plasmablasts in Pneumococcal Pneumonia and After Pneumococcal Polysaccharide and Pneumococcal Conjugate Vaccinations
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Palkola , N V , Pakkanen , S H , Kantele , J M , Pakarinen , L , Puohiniemi , R & Kantele , A 2015 , ' Differences in Homing Potentials of Streptococcus pneumoniae-Specific Plasmablasts in Pneumococcal Pneumonia and After Pneumococcal Polysaccharide and Pneumococcal Conjugate Vaccinations ' , Journal of Infectious Diseases , vol. 212 , no. 8 , pp. 1279-1287 . https://doi.org/10.1093/infdis/jiv208
| Title: | Differences in Homing Potentials of Streptococcus pneumoniae-Specific Plasmablasts in Pneumococcal Pneumonia and After Pneumococcal Polysaccharide and Pneumococcal Conjugate Vaccinations |
| Author: | Palkola, Nina V.; Pakkanen, Sari H.; Kantele, Jussi M.; Pakarinen, Laura; Puohiniemi, Ritvaleena; Kantele, Anu |
| Contributor organization: | Department of Bacteriology and Immunology Anu Kantele-Häkkinen Research Group Medicum Clinicum Department of Medicine Infektiosairauksien yksikkö |
| Date: | 2015-10-15 |
| Language: | eng |
| Number of pages: | 9 |
| Belongs to series: | Journal of Infectious Diseases |
| ISSN: | 0022-1899 |
| DOI: | https://doi.org/10.1093/infdis/jiv208 |
| URI: | http://hdl.handle.net/10138/225089 |
| Abstract: | Background. Mucosal immune mechanisms in the upper and lower respiratory tracts may serve a critical role in preventing pneumonia due to Streptococcus pneumoniae. Streptococcus pneumoniae-specific plasmablasts presumably originating in the lower respiratory tract have recently been found in the circulation in patients with pneumonia. The localization of an immune response can be evaluated by exploring homing receptors on such plasmablasts, yet no data have thus far described homing receptors in pneumonia. Methods. The expression of alpha(4)beta(7), L-selectin, and cutaneous lymphocyte antigen (CLA) on S. pneumoniae-specific plasmablasts was examined in patients with pneumonia (n = 16) and healthy volunteers given pneumococcal polysaccharide vaccine (PPV; n = 14) or pneumococcal conjugate vaccine (PCV; n = 11). Results. In patients with pneumonia, the proportion of S. pneumoniae-specific plasmablasts expressing L-selectin was high, the proportion expressing alpha(4)beta(7) was moderate, and the proportion expressing CLA was low. The homing receptor alpha(4)beta(7) was expressed more frequently in the pneumonia group than in the PPV (P=.000) and PCV (P=.029) groups, L-selectin was expressed more frequently in the PPV group than in the PCV group (P=.014); and CLA was expressed more frequently in the pneumonia group than in the PPV group (P=.001). Conclusions. The homing receptor profile in patients with pneumonia was unique yet it was closer to that in PCV recipients than in PPV recipients. These data suggest greater mucosal localization for immune response in natural infection, which is clinically interesting, especially considering the shortcomings of vaccines in protecting against noninvasive pneumonia. |
| Subject: |
pneumonia
Streptococcus pneumoniae pneumococcus pneumococcal polysaccharide vaccine PPV pneumococcal conjugate vaccine PCV mucosal immune response lymphocyte homing homing receptor ANTIBODY-SECRETING CELLS CUTANEOUS LYMPHOCYTE ANTIGEN COMMUNITY-ACQUIRED PNEUMONIA NASOPHARYNGEAL COLONIZATION T-CELLS B-CELLS ADHESION MOLECULES SALMONELLA-TYPHI IMMUNE-SYSTEM TISSUE BALT 3121 General medicine, internal medicine and other clinical medicine |
| Peer reviewed: | Yes |
| Rights: | cc_by_nc_nd |
| Usage restriction: | openAccess |
| Self-archived version: | publishedVersion |
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