Differences in Homing Potentials of Streptococcus pneumoniae-Specific Plasmablasts in Pneumococcal Pneumonia and After Pneumococcal Polysaccharide and Pneumococcal Conjugate Vaccinations

Show full item record



Permalink

http://hdl.handle.net/10138/225089

Citation

Palkola , N V , Pakkanen , S H , Kantele , J M , Pakarinen , L , Puohiniemi , R & Kantele , A 2015 , ' Differences in Homing Potentials of Streptococcus pneumoniae-Specific Plasmablasts in Pneumococcal Pneumonia and After Pneumococcal Polysaccharide and Pneumococcal Conjugate Vaccinations ' Journal of Infectious Diseases , vol. 212 , no. 8 , pp. 1279-1287 . DOI: 10.1093/infdis/jiv208

Title: Differences in Homing Potentials of Streptococcus pneumoniae-Specific Plasmablasts in Pneumococcal Pneumonia and After Pneumococcal Polysaccharide and Pneumococcal Conjugate Vaccinations
Author: Palkola, Nina V.; Pakkanen, Sari H.; Kantele, Jussi M.; Pakarinen, Laura; Puohiniemi, Ritvaleena; Kantele, Anu
Other contributor: University of Helsinki, Department of Bacteriology and Immunology
University of Helsinki, Infektiosairauksien yksikkö
University of Helsinki, Department of Bacteriology and Immunology
University of Helsinki, Department of Medicine





Date: 2015-10-15
Language: eng
Number of pages: 9
Belongs to series: Journal of Infectious Diseases
ISSN: 0022-1899
DOI: https://doi.org/10.1093/infdis/jiv208
URI: http://hdl.handle.net/10138/225089
Abstract: Background. Mucosal immune mechanisms in the upper and lower respiratory tracts may serve a critical role in preventing pneumonia due to Streptococcus pneumoniae. Streptococcus pneumoniae-specific plasmablasts presumably originating in the lower respiratory tract have recently been found in the circulation in patients with pneumonia. The localization of an immune response can be evaluated by exploring homing receptors on such plasmablasts, yet no data have thus far described homing receptors in pneumonia. Methods. The expression of alpha(4)beta(7), L-selectin, and cutaneous lymphocyte antigen (CLA) on S. pneumoniae-specific plasmablasts was examined in patients with pneumonia (n = 16) and healthy volunteers given pneumococcal polysaccharide vaccine (PPV; n = 14) or pneumococcal conjugate vaccine (PCV; n = 11). Results. In patients with pneumonia, the proportion of S. pneumoniae-specific plasmablasts expressing L-selectin was high, the proportion expressing alpha(4)beta(7) was moderate, and the proportion expressing CLA was low. The homing receptor alpha(4)beta(7) was expressed more frequently in the pneumonia group than in the PPV (P=.000) and PCV (P=.029) groups, L-selectin was expressed more frequently in the PPV group than in the PCV group (P=.014); and CLA was expressed more frequently in the pneumonia group than in the PPV group (P=.001). Conclusions. The homing receptor profile in patients with pneumonia was unique yet it was closer to that in PCV recipients than in PPV recipients. These data suggest greater mucosal localization for immune response in natural infection, which is clinically interesting, especially considering the shortcomings of vaccines in protecting against noninvasive pneumonia.
Subject: pneumonia
Streptococcus pneumoniae
pneumococcus
pneumococcal polysaccharide vaccine
PPV
pneumococcal conjugate vaccine
PCV
mucosal immune response
lymphocyte homing
homing receptor
ANTIBODY-SECRETING CELLS
CUTANEOUS LYMPHOCYTE ANTIGEN
COMMUNITY-ACQUIRED PNEUMONIA
NASOPHARYNGEAL COLONIZATION
T-CELLS
B-CELLS
ADHESION MOLECULES
SALMONELLA-TYPHI
IMMUNE-SYSTEM
TISSUE BALT
3121 Internal medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
440e3d86_4f2e_471b_8cd1_310345cdf477.pdf 378.9Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record