Acute doses of caffeine shift nervous system cell expression profiles toward promotion of neuronal projection growth

Show full item record



Permalink

http://hdl.handle.net/10138/225141

Citation

Yu , N Y , Bieder , A , Raman , A , Mileti , E , Katayama , S , Einarsdottir , E , Fredholm , B B , Falk , A , Tapia-Paez , I , Daub , C O & Kere , J 2017 , ' Acute doses of caffeine shift nervous system cell expression profiles toward promotion of neuronal projection growth ' , Scientific Reports , vol. 7 , 11458 . https://doi.org/10.1038/s41598-017-11574-6

Title: Acute doses of caffeine shift nervous system cell expression profiles toward promotion of neuronal projection growth
Author: Yu, Nancy Y.; Bieder, Andrea; Raman, Amitha; Mileti, Enrichetta; Katayama, Shintaro; Einarsdottir, Elisabet; Fredholm, Bertil B.; Falk, Anna; Tapia-Paez, Isabel; Daub, Carsten O.; Kere, Juha
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, University of Helsinki
Date: 2017-09-13
Language: eng
Number of pages: 10
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/225141
Abstract: Caffeine is a widely consumed psychoactive substance, but little is known about the effects of caffeine stimulation on global gene expression changes in neurons. Here, we conducted gene expression profiling of human neuroepithelial stem cell-derived neurons, stimulated with normal consumption levels of caffeine (3 mu M and 10 mu M), over a period of 9 h. We found dosage-dependent activation of immediate early genes after 1 h. Neuronal projection development processes were up-regulated and negative regulation of axon extension processes were down-regulated at 3 h. In addition, genes involved in extracellular matrix organization, response for wound healing, and regulation of immune system processes were down-regulated by caffeine at 3 h. This study identified novel genes within the neuronal projection guidance pathways that respond to acute caffeine stimulation and suggests potential mechanisms for the effects of caffeine on neuronal cells.
Subject: ADENOSINE RECEPTOR ANTAGONISTS
GENE-EXPRESSION
PARKINSONS-DISEASE
RYANODINE RECEPTOR
STEM-CELLS
COFFEE
DEMENTIA
RELEASE
RISK
TRANSCRIPTION
3111 Biomedicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s41598_017_11574_6.pdf 1.681Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record