Pelvic organ prolapse repair using the Uphold (TM) Vaginal Support System : a 1-year multicenter study

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Altman , D , Mikkola , T S , Bek , K M , Rahkola-Soisalo , P , Gunnarsson , J , Engh , M E , Falconer , C & Nordic TVM Grp 2016 , ' Pelvic organ prolapse repair using the Uphold (TM) Vaginal Support System : a 1-year multicenter study ' , International Urogynecology Journal , vol. 27 , no. 9 , pp. 1337-1345 . https://doi.org/10.1007/s00192-016-2973-0

Title: Pelvic organ prolapse repair using the Uphold (TM) Vaginal Support System : a 1-year multicenter study
Author: Altman, Daniel; Mikkola, Tomi S.; Bek, Karl Moller; Rahkola-Soisalo, Paivi; Gunnarsson, Jonas; Engh, Marie Ellstrom; Falconer, Christian; Nordic TVM Grp
Contributor organization: Clinicum
Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
Date: 2016-09
Language: eng
Number of pages: 9
Belongs to series: International Urogynecology Journal
ISSN: 0937-3462
DOI: https://doi.org/10.1007/s00192-016-2973-0
URI: http://hdl.handle.net/10138/225169
Abstract: The objective was to assess safety and clinical outcomes in women operated on using the Uphold (TM) Lite Vaginal Support System. We carried out a 1-year, multicenter, prospective, single cohort study of 207 women with symptomatic Pelvic Organ Prolapse Quantification (POP-Q) stage aeyen2 apical pelvic organ prolapse, with or without concomitant anterior vaginal wall prolapse. Safety data were collected using a standardized questionnaire. Anatomical outcome was assessed by the POP-Q and subjective outcomes by the Pelvic Floor Distress Inventory after 2 months and 1 year using a one-way repeated measures analysis of variance. Pain was evaluated using a visual analog scale. The overall rate of serious complications was 4.3 % (9 out of 207 patients), including 3 patients with bladder perforations, 1 with bleeding > 1,000 ml, 2 who had undergone re-operations with complete mesh removal because of pain, and 3 surgical interventions during follow-up because of mesh exposure. POP-Q stage aecurrency sign1 after 1 year was 94 % and subjective symptom relief was reported by 91 % of patients (p <0.001). Pain after 2 months and 1 year was 60 % lower compared with the preoperative mean (p <0.001). Minor complications occurred in 20 women (9.7 %) and were dominated by lower urinary tract dysfunction. No predisposing risk factors for complications were found. The Uphold (TM) Lite procedure in women with apical pelvic organ prolapse provided satisfactory restoration of vaginal topography and symptom relief. However, serious complication rates were largely comparable with those of other transvaginal mesh kits.
Subject: Complications
Mesh
Pelvic organ prolapse
RANDOMIZED CONTROLLED-TRIAL
TRANSVAGINAL MESH
ABDOMINAL SACROCOLPOPEXY
ANTERIOR
SURGERY
OUTCOMES
3123 Gynaecology and paediatrics
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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