Effect of Vitamin D, Calcium and Multiple Micronutrients Supplementation on Lipid Profile in Pre-menopausal Bangladeshi Garment Factory Workers with Hypovitaminosis D

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Islam , M Z , Shamim , A A , Akhtaruzzaman , M , Karkkainen , M & Lamberg-Allardt , C 2014 , ' Effect of Vitamin D, Calcium and Multiple Micronutrients Supplementation on Lipid Profile in Pre-menopausal Bangladeshi Garment Factory Workers with Hypovitaminosis D ' Journal of Health Population and Nutrition , vol. 32 , no. 4 , pp. 687-695 .

Title: Effect of Vitamin D, Calcium and Multiple Micronutrients Supplementation on Lipid Profile in Pre-menopausal Bangladeshi Garment Factory Workers with Hypovitaminosis D
Author: Islam, Md. Zahirul; Shamim, Abu Ahmed; Akhtaruzzaman, Mohammad; Karkkainen, Merja; Lamberg-Allardt, Christel
Contributor: University of Helsinki, Department of Food and Nutrition
University of Helsinki, Department of Food and Nutrition
University of Helsinki, Department of Food and Nutrition
Date: 2014
Language: eng
Number of pages: 9
Belongs to series: Journal of Health Population and Nutrition
ISSN: 1606-0997
URI: http://hdl.handle.net/10138/225339
Abstract: Elevated total cholesterol and low-density lipoprotein cholesterol in sera are both well-known risk factors of coronary heart disease. Adequate vitamin D status is important for optimal function of many organs and tissues of our body. There is continuing controversy about the effect of adequate vitamin D consumption on serum lipids and lipoproteins. The present study assessed the effect of vitamin D, calcium and multiple micronutrients supplementation on the lipid profile in Bangladeshi young female garment factory workers who have hypovitaminosis D. This placebo-controlled intervention trial conducted over a period of one year randomly assigned a total of 200 apparently healthy subjects aged 16-36 years to 4 groups. The subjects received daily supplements of 400 IU of vitamin D (VD group) or 400 IU of vitamin D+ 600 mg of calcium lactate (VD-Ca group), or multiple micronutrients with 400 IU of vitamin-D+ 600 mg of calcium lactate (MMN-VD-Ca group), or the group consuming placebo (PL group). Serum concentrations of lipid and lipoprotein, 25-hydroxyvitamin D (25OHD) and intact parathyroid hormone (iPTH) were measured at baseline and after one year of follow-up. No significant changes in the serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), LDL-C/HDL-C ratio were observed in the supplemented groups compared to the placebo group. Supplementation had a positive effect (p<0.05) on very low-density lipoprotein cholesterol (VLDL-C) and triacylglycerol (TAG). A negative correlation between changes in serum iPTH and HDL-C was observed, which indicated that subjects with the greatest decline in S-iPTH had the greatest increase in HDL-C. The results suggest that consumption of adequate vitamin D with calcium or MMN for one-year may have no impact on serum lipid profile in the subjects studied. Longer-term clinical trials with different doses of supplemental vitamin D are warranted in evaluating the effect of intervention.
Subject: Female garment workers
HDL-cholesterol
LDL-cholesterol
Total cholesterol
Triacylglycerol
Vitamin D intervention
Bangladesh
25-HYDROXYVITAMIN-D LEVELS
HEALTH OUTCOMES
BLOOD-PRESSURE
RISK
PREVENTION
DISEASE
STROKE
WOMEN
MEN
416 Food Science
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